首页|Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats

Grifola frondosa polysaccharides alleviate Alzheimer's disease in rats

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Objective:To evaluate the effect of Grifola frondosa polysaccharides(GFP)in a rat model of Alzheimer's disease(AD).Methods:Seventy-five rats were divided into five groups:the normal control group and the AD group treated with or without GFP(100,200,and 400 mg/kg).Behavioral responses in the open field test and elevated plus maze test were assessed.Additionally,the levels of malondialdehyde and ferric-reducing ability of plasma,and the mRNA expressions of TNF-α,IL-6,and IL-1β in the hippocampus were measured.Results:Treatment with GFP significantly improved AD-induced behavioral changes in the open field test and elevated plus maze test(P<0.05).In addition,the level of malondialdehyde and the mRNA expressions of TNF-α,IL-6,and IL-1β were decreased by GFP treatment in a dose-dependent manner in AD rats(P<0.05),while the level of ferric-reducing ability of plasma was significantly increased(P<0.05).Conclusions:Oral administration of GFP can reduce inflammation and oxidative stress,as well as improve behavioral responses associated with AD,suggesting its potential use in AD treatment.However,additional studies are needed to elucidate its underlying mechanisms and efficacy.

Grifola frondosaPolysaccharidesDementiaBehavioral responsesInflammationAlzheimer's disease

Samira Behrad、Sina Pourranjbar、Mohammad Pourranjbar、Saeid Abbasi-Maleki、Samira Rostami Mehr、Reza Hossein Gholizadeh Salmani、Nasrollah Moradikor

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Department of Oral and Maxillofacial Pathology,Dental School,Semnan University of Medical Sciences,Semnan,Iran

Faculty of Medicine,Kerman University of Medical Sciences,Kerman,Iran

Department and Neuroscience Research Center,Kerman University of Medical Sciences,Kerman,Iran

Pharmaceutical Sciences Research Center,Health Institute,Kermanshah University of Medical Sciences,Kermanshah,Iran

Department of Basic Sciences,Faculty of Veterinary Medicine,Urmia University,Urmia,Iran

International Center for Neuroscience Research,Institute for Intelligent Research,Tbilisi,Georgia

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2024

10.4103/apjtb.apjtb_294_24

亚太热带生物医学杂志(英文版)

亚太热带生物医学杂志(英文版)

ISSN：
年,卷(期)：2024.14(11)