首页|Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats

Cardioprotective effects of total and anthocyanin-rich extracts of Opuntia ficus-indica fruit on epinephrine-induced cardiac injury in rats

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Objective:To examine the effect of fruit extracts of Opuntia ficus-indica on epinephrine-induced myocardial injury in rats.Methods:Rats were pre-treated with hydroalcoholic and anthocyanin-rich extracts(250,500,and 1 000 mg/kg)orally for 16 days.Epinephrine(2 mg/kg)was injected subcutaneously on days 15 and 16.Then ECG,heart rate,RR interval,cardiac histopathology,and serum parameters of cardiac damage and oxidative stress were evaluated.Results:Pretreatment with the hydroalcoholic and anthocyanin-rich extracts of Opuntia ficus-indica at doses of 500 and 1 000 mg/kg reversed epinephrine-induced changes in ECG,heart rate,RR interval,and cardiac histopathology,and attenuated creatine phosphokinase-MB activity and malondialdehyde level.The extracts at all doses diminished heart weight,lactate dehydrogenase,and aspartate aminotransferase,and also elevated total antioxidant capacity.However,1 000 mg/kg of the anthocyanin-rich extract was more effective than the hydroalcoholic extract.Conclusions:Supplementation with fruit extracts of Opuntia ficus-indica,especially anthocyanin-rich extract,could protect against epinephrine-induced cardiac injury in rats by alleviating electrocardiographic,biochemical,histopathological,and oxidative stress parameters,and may be used in the treatment of cardiovascular diseases.

Opuntia ficus-indicaAntioxidantCardiovascular diseasesEpinephrineCardiac injuriesLipid peroxidation

Leila Safaeian、Masoud Sadeghi-Dinani、Zahra Haghighatian、Mohammad-Bagher Fatahian、Marjan Khademizadeh

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Department of Pharmacology and Toxicology,Pharmaceutical Sciences Research Center,School of Pharmacy and Pharmaceutical Sciences,Isfahan University of Medical Sciences,Isfahan,Iran

Department of Pharmacognosy,School of Pharmacy and Pharmaceutical Sciences,Isfahan University of Medical Sciences,Isfahan,Iran

Department of Pathology,School of Medicine,Lorestan University of Medical Sciences,Khorramabad,Iran

Pharmaceutical Sciences Research Center,School of Pharmacy and Pharmaceutical Sciences,Isfahan University of Medical Sciences,Isfahan,Iran

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2024

10.4103/apjtb.apjtb_485_24

亚太热带生物医学杂志(英文版)

亚太热带生物医学杂志(英文版)

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年,卷(期)：2024.14(12)