微单倍型遗传标记的研究进展及在动物保护上的应用潜力
Advances on Microhaplotype Genetic Markers and Application Potentials in Conservation of Animals
谢大鑫 1许蔚 2沈富军 2张修月3
作者信息
- 1. 四川大学生命科学学院,生物资源与生态环境教育部重点实验室,成都,610065
- 2. 成都大熊猫繁育研究基地,成都,610081;四川省濒危野生动物保护生物学重点实验室,成都,610081
- 3. 四川大学生命科学学院,生物资源与生态环境教育部重点实验室,成都,610065;四川省濒危野生动物保护生物学重点实验室,成都,610081
- 折叠
摘要
新型遗传标记微单倍型,凭借高稳定性、无"stutter"峰干扰、高多态性、短扩增片段和SNP位点需求量少等显著优势逐渐受到法医物证学、种群遗传学等领域研究人员的关注,并在亲缘关系分析与亲子鉴定方面得到较好应用.本文逐一综述了微单倍型的发展、命名规则与筛选标准等,回顾了微单倍型数据获取、分析与检测的研究进展,首次对微卫星、SNP和微单倍型3种遗传标记进行了全面比较,并介绍了微单倍型遗传标记在动物学领域的应用潜力及面临的挑战与机遇,期冀为相关研究提供参考.
Abstract
The microhaplotype,as a kind of new genetic marker,has gradually attracted the attention of researchers in the fields of forensic genetics and population genetics in capable of their high stability,no interference from"stutter"peaks,high polymorphisms,short amplification fragments and fewer SNP locus requirements,and has been well applied in kinship analysis and paternity testing.This paper reviews the developments,nomenclature and screening criteria of the microhaplo-types,retrospects the progress of data acquisition,analysis and detection,comprehensively compares the microhaplo-types with the microsatellites and SNPs at first,and introduces the application potentials,challenges and opportunities of the microhaplotype genetic markers in zoology,with the hope of providing a reference for related research.
关键词
微单倍型/遗传标记/发展演变/动物学应用潜力Key words
Microhaplotype/Genetic markers/Evolution/Application potential of zo-ology引用本文复制引用
基金项目
四川省自然科学基金重点项目(2022NSFSC0009)
出版年
2024
NETL
NSTL
维普
万方数据