The factors for potential failures in spacecrafts include the effects of the harsh space environment on it during the on-orbit servicing, manufacturing quality as well as the work load during service, which all have significant impacts on its service life and reliability. Therefore, it is of great scientific and technical importance to analyze potential failure mechanism and failure modes in the spacecrafts. In this paper, the types of failures and the relationship of the causes of potential failures, failure modes, failure mechanism and influencing factors for a space structure are discussed. Additionally, fifteen factors classified as three categories that could lead to potential failures of the spacecrafts are presented. It is concluded that the friction and wear phenomena resulted from lubrication failure and fatigue failure related to the loading are two major potential causes of failure in space structure. Pro-cedures and strategies for the analysis of failure mechanism are proposed.