Abstract
Background:The aim of the study was to investigate the changes in the periarterial capillary-free zone(paCFZ)after anti-vascular endothelial growth factor(VEGF)therapy in patients with branch retinal vein occlusion(BRVO)by wide-field swept-source optical coherence tomography angiography(SS-OCTA)and assess their associations with clinical outcomes.Methods:In this retrospective observational study of 54 treatment-naive BRVO patients with macular edema,we reviewed the findings of 12 × 12 mm2 SS-OCTA at baseline,3,6,and 12 months after intravitreal ranibizumab injec-tions.The paCFZ and major retinal artery areas were measured on SS-OCTA images.The paCFZ area to artery area(P/A)ratio was calculated.Results:The paCFZ areas and P/A ratios of first-and second-order arteries were significantly greater in BRVO eyes than in contralateral eyes(all P＜0.01),but there were no differences in the first-and second-order artery areas(P=0.20 and 0.25,respectively).The paCFZ areas and P/A ratios decreased significantly at 3,6,and 12 months after anti-VEGF therapy(all P＜0.01).The baseline P/A ratio was significantly correlated with the baseline best-corrected visual acuity(BCVA),central retinal thickness,and their improvements at 3,6,and 12 months(all P＜0.05).Baseline BCVA and P/A ratios of first-and second-order arteries were independently associated with the final BCVA in multivari-ate linear regression.Conclusions:Wide-field SS-OCTA shows that anti-VEGF therapy can lead to a significant improvement in the paCFZ parameters in BRVO.Smaller baseline P/A ratios on SS-OCTA tend to predict better visual outcomes at 12 months after anti-VEGF therapy.
基金项目
国家自然科学基金(82101150)
国家自然科学基金(82171078)
Shanghai Clinical 3-year Action Planmajor Clinical Research(SHDC2020CR2041B)
Shanghai Clinical 3-year Action Planmajor Clinical Research(SHDC2020CR5014-003)
Shanghai Sailing Program(21YF1405300)
上海市科委项目(20Y11911100)
上海市科委项目(18411965100)
NETL
NSTL
万方数据