Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children:exploratory analysis of clinical trials for myopia progression

Meiping Xu ¹Xinping Yu ¹Minghui Wan ¹Kemi Feng ¹Junxiao Zhang ²Meixiao Shen ¹Bj?rn Drobe ³Hao Chen ¹Jia Qu ¹Jinhua Bao²

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作者信息

1. Eye Hospital and School of Ophthalmology and Optometry,Wenzhou Medi-cal University,Wenzhou,Zhejiang,China;National Clinical Research Center for Ocular Diseases,Wenzhou,Zhejiang,China
2. Eye Hospital and School of Ophthalmology and Optometry,Wenzhou Medi-cal University,Wenzhou,Zhejiang,China;National Clinical Research Center for Ocular Diseases,Wenzhou,Zhejiang,China;WEIRC,WMU-Essilor Inter-national Research Center,Wenzhou,Zhejiang,China
3. WEIRC,WMU-Essilor Inter-national Research Center,Wenzhou,Zhejiang,China;R&D Vision Sciences AMERA,Essilor International,Singapore,Singapore
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Abstract

Background:With increasing axial length(AL)and myopia progression,the micro-structure of the retina and choroid gradually changes.Our study describes the longitudinal changes in retinal and choroidal thickness in school-aged children with myopia and explores the relationship between changes in choroidal thickness and myopia progression.Methods:An exploratory analysis of a randomized trial was performed.Children(n=168,aged 7 to 12 years)with myopia from-0.75 diopter(D)to-4.00 D were enrolled in this prospective longitudinal study.Cycloplegic refrac-tion,AL,retinal and choroidal thicknesses were measured at baseline and at 1-and 2-year follow-ups."Rapid progression myopia"was defined as increasing in myopia＞1.00 D and"stable progression myopia"was＜1.00 D during the 2-year follow-up.Factors affecting the changes in choroidal thickness were analysed using linear mixed models.Results:AL significantly increased by 0.67 士0.24 mm with a myopic shift of-1.50±0.64 Dover the 2 years.The overall retinal thickness increased from 251.12±15.91 μm at baseline to 253.47±15.74 μm at the 2-year follow-up(F=23.785,P＜0.001).The subfoveal choroidal thickness decreased from 231.03±54.04 μm at baseline to 206.53±59.71 μm at the 2-year follow-up(F=73.358,P＜0.001).Choroidal thinning was significantly associated with AL elongation(β=-43.579 μm/mm,P=0.002)and sex(β=-17.258,P=0.001).Choroidal thickness continued to decrease in subjects with rapid progression(F=92.06,P＜0.001)but notin those with steady progression(F=2.23,P=0.119).Conclusion:Significant choroidal thinning was observed and was associated with rapid progression and sex.These findings indicate a need to understand the role of the choroid in eye growth and myopia development.Synopsis/Precis:The macular choroidal thickness of myopic children is relevant to different degrees of myopic progression in this 2-year longitudinal study.These findings suggest that control of choroidal thickness might work to regulate human ocular growth.

Key words

Axial length/Choroidal thickness/Children/Myopia/Spectral-domain optical coherence tomography

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基金项目

浙江省重点研发计划(2021C03102)

国家国际科技合作专项(2014DFA30940)

Essilor International S.A()

浙江省自然科学基金(LY19H120004)

出版年

2024

眼视光学杂志(英文版)

ISSN：

段落导航