The aim of this study is to improve the leaching efficiency of zinc and germanium in high silicon and low germanium zinc oxide dust by introducing ultrasonic co-oxidant.Hydrogen peroxide was used as the oxidizer.The initial sulfuric acid concentration,liquid-solid ratio,molar concentration ratio of H2O2 to H2SO4,temperature,and ultrasonic power were optimized.The results show that when the initial concentration of sulfuric acid was 1.8 mol/L,the concentration ratio of hydrogen peroxide to sulfuric acid was 1∶1,the liquid-solid mass ratio was 7,the leaching time was 60 min,the leaching temperature was 70℃,and the ultrasonic power was 300 W,the leaching rates of zinc and germanium reached the highest value,and the leaching rates of zinc and germanium were 98.16%and 86.14%,respectively.Compared with the conventional process without ultrasonic and hydrogen peroxide under the same conditions,the leaching rates of the two methods are increased by 14.66%and 17.37%respectively.In addition,the study also analyzed the reaction mechanism in the leaching process,which provided a theoretical basis for the subsequent process optimization.