血清谷氨酰转肽酶和骨桥蛋白在无症状继发性胆总管结石诊断中的临床意义
Diagnositic value of serum glutamyltransferase and osteopontin for asymptomatic secondary common bile duct stones
丁守勇 1鲍胜华 1张卫东 1王东1
作者信息
- 1. 皖南医学院弋矶山医院肝胆一科,安徽芜湖 241001
- 折叠
摘要
目的 探讨血清谷氨酰转肽酶(GGT)联合骨桥蛋白(OPN)对无症状继发性胆总管结石的诊断价值.方法 将2016年月3月至2018年8月皖南医学院弋矶山医院收治的150例胆囊结石患者按照结石来源分为无症状继发性胆总管结石(胆总管结石组)34例和单纯胆囊结石(胆囊结石组)116例,比较两组患者肝功能指标和血清OPN含量的差异,建立受试者工作特征曲线(ROC)以评价血清GGT联合OPN对无症状继发性胆总管结石的诊断效能.结果 两组患者丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBil)、直接胆红素(DBil)比较差异无统计学意义(P＞0.05),胆总管结石组 GGT、碱性磷酸酶(ALP)、OPN 明显高于胆囊结石组[(141.57 ± 47.11)U/L 比(77.26 ± 21.76)U/L、(150.10 ± 17.55)U/L 比(137.65 ± 24.36)U/L、(16.21 ± 3.26)mg/L比(11.50 ± 3.99)mg/L],差异有统计学意义(P﹤0.05).多因素分析结果表明, GGT、ALP、OPN是影响无症状继发性胆总管结石的独立危险因素(均P﹤0.05).GGT、OPN诊断无症状继发性胆总管结石的曲线下面积(AUC)明显高于ALP(均P﹤0.05).结论 血清OPN和GGT可以作为胆囊结石合并无症状继发性胆总管结石早期筛查的指标.
Abstract
Objective To explore the diagnostic value of serum glutamyltransferase (GGT) and osteopontin (OPN) for asymptomatic secondary common bile duct stones. Methods A total of 150 gallbladder stones patients were divided into asymptomatic secondary common bile duct stones patients (common bile duct stones group) 34 cases and gallbladder stone group 116 cases. The difference of serum liver function indexes and OPN concentration between 2 groups were compared. Meanwhile, the diagnostic value of serum GGT combined with OPN was assessed by receiver operating characteristic curve. Results There were no statistical difference in alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil) and direct bilirubin (DBil) between 2 groups (P＞0.05). The GGT, alkaline phosphatase (ALP) and OPN in common bile duct stones were significantly higher than those in gallbladder stone group: (141.57 ± 47.11) U/L vs. (77.26 ± 21.76) U/L, (150.10 ± 17.55) U/L vs. (137.65 ± 24.36) U/L and (16.21 ± 3.26) mg/L vs. (11.50 ± 3.99) mg/L, there were statistical differences (P﹤0.05). Logistic multivariate analysis showed that GGT, ALP and OPN were the independent risk factors of asymptomatic secondary common bile duct stones (P﹤0.05). The areas under curve of GGT and OPN in diagnosis of asymptomatic secondary common bile duct stones were significantly higher than ALP (P﹤0.05). Conclusions Serum GGT and OPN can be served as early predictors for the gallbladder stone combine with asymptomatic secondary common bile duct stones.
关键词
骨桥蛋白质/胆囊结石病/谷氨酰转肽酶/无症状继发性胆总管结石Key words
Osteopontin/Cholecystolithiasis/Glutamyltransferase/Asymptomatic secondary bile duct stones引用本文复制引用
出版年
2019
NETL
NSTL
维普
万方数据