The original blasting parameters of Hongtoushan Copper Zinc Mine are no longer suitable for the current mechanized min-ing scheme.In order to achieve safe,economic,and efficient mining goals,theoretical analysis and on-site industrial experiments were combined to optimize the blasting parameters from aspects such as ore block rate,drilling efficiency,explosive unit consump-tion,and economic benefits.The results show that the triangular arrangement of the blast holes is superior to the rectangular arrange-ment,and the mesh size of the blast holes is determined to be 1.5 m×1.3 m,the ore block rate is reduced,the drilling efficiency is increased by three times,the explosive consumption is reduced by 27%,and the economic benefits are improved.