哮喘患儿血清MP-IgM抗体与潮气肺功能和FeNO水平的相关性研究
Correlation analysis between serum MP-IgM and tidal pulmonary function and FeNO level in children with asthma
刘晓秋 1晏世玲 1蒋昌科1
作者信息
- 1. 重庆市永川区妇幼保健院,重庆 402160
- 折叠
摘要
目的 探讨哮喘患儿血清肺炎支原体IgM(MP-IgM)抗体与潮气肺功能、呼出气一氧化氮(FeNO)水平的相关性.方法 选取2020年9月～2021年12月在重庆市永川区妇幼保健院儿科住院并确诊为哮喘的患儿100例,分别在急性发作期和缓解期检测患儿血清MP-IgM抗体、潮气肺功能指标和FeNO,对比不同时期MP-IgM抗体阳性率,分析血清MP-IgM抗体与潮气肺功能指标和FeNO水平间的相关性.结果 急性发作期MP-IgM抗体阳性率为37%,显著高于缓解期的18.0%(P＜0.05).在急性发作期,MP-IgM抗体阳性患儿的达峰时间比(TPTEF/TE)和达峰容量比(VPEF/VE)显著低于MP-IgM抗体阴性组(P＜0.05);MP-IgM抗体阳性组的FeNO水平高于MP-IgM抗体阴性组(P＜0.05).在缓解期,MP-IgM抗体阳性患儿FeNO水平显著高于MP-IgM抗体阴性组(P＜0.05),而TPTEF/TE、VPEF/VE在MP-IgM抗体阳性组和阴性组的差异无统计学意义(P＞0.05).相关性分析显示,在急性发作期,患儿的TPTEF/TE与MP-IgM抗体阳性呈负相关(r=-0.250,P=0.012).在缓解期,患儿的FeNO与MP-IgM抗体阳性呈正相关(r=0.410,P=0.000).结论 肺炎支原体感染与哮喘急性发作和气道炎症控制不良相关,对于优化现有的临床评估方案具有一定的临床意义.
Abstract
Objective To study the correlation between serum Mycoplasma pneumoniae IgM(MP-IgM)and tidal pulmonary function and fractional exhaled nitric oxide(FeNO)level in children with asthma.Methods A total of 100 children with asthma admitted to the Pediatric Department of Yongchuan District Maternal and Child Health Hospital in Chongqing from September 2020 to December 2021 were selected.Serum MP-IgM,tidal pulmonary function and FeNO were detected during acute attack period and remission period,and the positive rate of MP-IgM was compared in different periods.The correlation between serum MP-IgM and tidal pulmonary function index and FeNO level was analyzed.Results The positive rate of MP-IgM in acute attack period was 37%,which was significantly higher than 18.0%in remission period(P＜0.05).In the acute attack period,the ratio of the time to reach peak tidal expiratory flow to the total expiratory time(TPTEF/TE)and ratio of volume to peak expiratory flow to total expiratory volume(VPEF/VE)of MP-IgM-positive patients were significantly lower than those of MP-IgM-negative patients(P＜0.05);The FeNO level of MP-IgM-positive patients was higher than that of MP-IgM-negative patients(P＜0.05).In remission period,FeNO level in MP-IgM-positive patients was significantly higher than that in MP-IgM-negative patients(P＜0.05);However,there was no significant difference in TPTEF/TE and VPEF/VE between MP-IgM-positive and negative patients(P＞0.05).Correlation analysis showed that the TPTEF/TE value was negatively correlated with positive MP-IgM antibody in the acute attack period(r=-0.250,P=0.012),and FeNO level was positively correlated with positive MP-IgM antibody in remission period(r=0.410,P=0.000).Conclusion Mycoplasma pneumoniae infection is associated with acute attack period of asthma and poor control of airway inflammation.This study has certain clinical significance for optimizing existing clinical evaluation protocols.
关键词
儿童哮喘/肺炎支原体/潮气肺功能/呼出气一氧化氮Key words
Childhood asthma/Mycoplasma pneumoniae/Tidal pulmonary function/Exhaled nitric oxide引用本文复制引用
基金项目
重庆市卫生健康委妇幼科研培育临床项目(2021)(2021FY112)
重庆市永川区自然科学基金(2021)(2021ycjckx20003)
出版年
2024
NETL
NSTL
万方数据