Objective To study the safety and feasibility of total laparoscopic pancreaticoduodenectomy in primary hospitals.Methods A retrospective analysis was conducted on cases of total laparoscopic pancreaticoduodenectomy performed in Binzhou Central Hospital from January 2021 to May 2023.Results 2 cases were excluded because of the need for palliative surgery due to intraperitoneal metastasis found by laparoscopic exploration.Total laparoscopic pancreaticoduodenectomy was successfully completed in 10 cases.The operation duration was(277.00±23.92)min,and the intraoperative bleeding was(266.30±125.41)ml.Postoperative 1 case had grade B pancreatic fistula and 1 case had a small amount of biliary fistula.No tumor recurrence was observed during 1~14 months of follow-up.Conclusion It is safe and feasible to carry out total laparoscopic pancreaticoduodenectomy in primary hospitals,but surgical teams with experience in open pancreaticoduodenectomy,high-definition laparoscopic equipment,and experienced laparoscopic resection and suture techniques are required.At the early stage,it can be carried out under the guidance of professors in superior hospitals.