Objective To investigate the clinical value of thrombelastogram(TEG)and B-type natriuretic peptide(BNP)in evaluating the severity of acute pulmonary embolism(APE).Methods 40 patients with APE admitted to our hospital from May 2022 to April 2023 were selected as the observation group,and 50 healthy subjects were included as the control group.The observation group was divided into low-risk group(n=18),medium-risk group(n=13)and high-risk group(n=9)according to the the risk of patients.TEG and BNP levels of all subjects were measured.The correlation between TEG indexes and BNP levels and the severity of APE and its predictive value for APE were analyzed.Results There were significant differences in BNP level,coagulation reaction time(R),maximum blood clot strength(MA),blood coagulation time(K)and coagulation angle(α)among the four groups(P<0.05).With the aggravation of the disease,the BNP level,MA and α increased significancly,and R and K decreased.Compared with the control group,BNP level,MA and α were increased in the low-risk group,medium-risk group and high-risk group,and R and K were shortened(P<0.05).There were significant differences in TEG indexes and BNP levels between different risk groups(P<0.05).Pearson correlation analysis showed that BNP level,MA and α were positively correlated with the severity of APE patients(P<0.05),while R and K were negatively correlated with the severity of APE patients(P<0.05).The sensitivity and specificity of TEG indexes combined with BNP in predicting APE were 92.36%and 87.73%,which were higher than those of other indicators detection alone.Conclusion TEG and BNP can be used to evaluate the severity of patients with APE,and the combined detection of the two has a high predictive value for APE.
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