医师在线2024,Vol.14Issue(9) :81-83.

连续性肾脏替代治疗患者更昔洛韦剂量调整策略的个案分析

Dose adjustment strategies for ganciclovir in patients undergoing continuous renal replacement therapy:A case analysis

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医师在线2024,Vol.14Issue(9) :81-83.

连续性肾脏替代治疗患者更昔洛韦剂量调整策略的个案分析

Dose adjustment strategies for ganciclovir in patients undergoing continuous renal replacement therapy:A case analysis

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作者信息

  • 1. 广州市第十二人民医院,广州 510630
  • 折叠

摘要

临床药师通过参与1例因肾功能衰竭接受连续性肾脏替代治疗伴巨细胞病毒感染患者的会诊,在综合考虑患者的临床感染情况、肾功能、体外肾脏替代治疗的影响及药物特性等因素后,适时调整了更昔洛韦的用药剂量,最终患者的感染得到控制,且肾功能维持稳定.结合文献回顾发现,当前研究对连续性肾脏替代治疗患者使用更昔洛韦的剂量调整建议存在不足,主要针对无尿患者.临床医生需根据患者的实际情况及药物的水溶性、血浆蛋白结合率等多种因素,及时调整用药剂量,以免延误治疗.

Abstract

By participating in the consultation of a patient with renal failure receiving continuous renal replacement therapy(CRRT)complicated by cytomegalovirus infection,the clinical pharmacist comprehensively considered the patient's clinical infection status,renal function,the impact of CRRT and the characteristic of the medication.The pharmacist timely adjusted the dosage of ganciclovir,ultimately controlling the infection and maintaining stable renal function.A literature review revealed that current research lacks sufficient dosage adjustment recommendations for ganciclovir in CRRT patients,often focusing on anuric patients.Clinicians need to adjust medication dosages promptly based on the patient's actual condition,drug solubility,plasma protein binding rate and other factors to avoid delaying treatment.

关键词

连续性肾脏替代治疗/更昔洛韦/肾功能衰竭/药学监护/剂量调整/巨细胞病毒感染

Key words

Continuous renal replacement therapy/Ganciclovir/Renal failure/Pharmaceutical monitoring/Dose adjustment/Cytomegalovirus infection

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出版年

2024
医师在线

医师在线

ISSN:
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