Objective To study the effects of obesity in high altitude areas on the level of blood lipid and lung function in children with asthma.Methods A total of 98 children with asthma admitted to the pediatric care clinic and inpatient department of the affiliated hospital of Qinghai University from September 2021 to December 2023 were selected and divided into general asthma group(n=50)and obese asthma group(n=48)according to body mass index(BMI).At the same time,100 non-asthmatic children were collected and divided into normal physical examination group(n=50)and simple obesity group(n=50)according to BMI.The blood lipid levels and lung function among all groups were compared,and the correlation between BMI and lung function in children with asthma was analyzed.Results The comparison of blood lipid levels showed that the high-density lipoprotein cholesterol(HDL-C)level of the simple obesity group was lower than that of the normal physical examination group,the HDL-C level of the obese asthma group was lower than that of the ordinary asthma group,the HDL-C level of the ordinary asthma group was lower than that of the normal physical examination group,and the HDL-C level of the obese asthma group was lower than that of the simple obesity group,with statistical significance(P<0.05).The comparison of lung function level showed that the forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1)of the simple obesity group were lower than those of the normal physical examination group,and the FVC,FEV1 and FEV1/FVC of the obese asthma group were lower than those of the common asthma group,the differences were statistically significant(P<0.05).BMI in children with asthma was negatively correlated with FVC,FEV1 and FEV1/FVC(r=-0.357,-0.383,-0.352,P<0.001).There was no significant correlation with peak expiratory flow(PEF)(r=-0.163,P=0.108).Conclusion There is a certain correlation between obesity,asthma and dyslipidemia in children at high altitude.Obesity can cause dyslipidemia and lung function impairment in children with asthma and normal children.BMI is negatively correlated with lung function in children with asthma.
关键词
肥胖/支气管哮喘/血脂/肺功能
Key words
Obesity/Bronchial asthma/Blood lipid/Lung function
维普
万方数据