养胃颗粒对慢性萎缩性胃炎患者舌苔菌群的影响
Effect of Yangwei Granules on tongue coating flora in patients with chronic atrophic gastritis
闻瑜 1许冬佳 1沈贤 1鲁林杰 1翟浩亮1
作者信息
- 1. 海宁市人民医院消化内科,浙江海宁 314400
- 折叠
摘要
目的 探讨养胃颗粒对慢性萎缩性胃炎(CAG)患者舌苔菌群的影响.方法 选取2021年1月～2022年12月在海宁市人民医院体检的健康体检者7例为A组,不予任何干预;并选取同期消化内科收治的CAG患者7例,以养胃颗粒治疗前为B组、养胃颗粒治疗后为C组.采集三组受检者的舌苔菌群标本,结合高通量基因测序技术获得各组的舌苔微生物信息,分析CAG患者与健康人群舌苔样本微生物群落的差异,以及养胃颗粒治疗前后CAG患者舌苔菌群的变化.结果 在属水平上,各组物种群落构成、菌属含量、优势菌属不同,B组和A组在属水平的各物种丰度较C组多.与A组相比,B组消化链球菌属(Peptostreptococcus)的丰度显著偏低(P＜0.05),B组毛绒厌氧杆菌属(Lachnoanaerobaculum)的丰度显著偏高(P＜0.05),C组普雷沃菌属_7(Prevotella_7)、消化链球菌属(Peptostreptococcus)、缠结优杆菌属(Eubacterium_nodatum_group)的丰度显著偏低(P＜0.05),C组链球菌属(Streptococcus)的丰度显著偏高(P＜0.05);B组毛绒厌氧杆菌属(Lachnoanaerobaculum)、消化链球菌属(Peptostreptococcus)、梭菌属_UCG-014(Clostridia_UCG-014)的丰度显著比C组高(P＜0.05).结论 养胃颗粒能使CAG患者的舌苔菌群在治疗前后发生变化,可能影响舌苔的微观机理.
Abstract
Objective To investigate the effect of Yangwei Granules on tongue coating flora in patients with chronic atrophic gastritis(CAG).Methods A total of 7 healthy subjects who underwent physical examination in Haining People's Hospital from January 2021 to December 2022 were selected as group A without any intervention.And 7 patients with CAG admitted to the Department of Gastroenterology during the same period were selected.The patients before treatment with Yangwei Granules were in group B,and the patients after treatment with Yangwei Granules were in group C.The tongue coating flora specimens of the 3 groups of subjects were collected,and the information of tongue coating microorganisms in each group was obtained by high-throughput gene sequencing technology.The differences in the microbial communities of tongue coating samples between CAG patients and healthy subjects,and the changes of tongue coating flora in CAG patients before and after treatment with Yangwei Granules were analyzed.Results At the genus level,the species community composition,genus content and dominant genus of tongue coating species in the 3 groups were different.The abundance of each species in group B and group A was higher than that in group C at the genus level.Compared with Group A,the abundance of Peptostreptococcus in group B was significantly lower(P<0.05),the abundance of Lachnoanaerobaculum in group B was significantly higher(P<0.05),the abundance of Prevotella_7,Peptostreptococcus and Eubacterium_nodatum_group in group C was significantly lower(P<0.05),and the abundance of Streptococcus in group C was significantly higher(P<0.05).The abundance of Lachnoanaerobaculum,Peptostreptococcus and Clostridium_UCG-014 in group B was significantly higher than that in group C(P<0.05).Conclusion Yangwei Granules can change the tongue coating flora of CAG patients before and after treatment,which may affect the microscopic mechanism of tongue coating.
关键词
慢性萎缩性胃炎/养胃颗粒/舌苔菌群/高通量基因测序技术Key words
Chronic atrophic gastritis/Yangwei Granules/Tongue coating flora/High-throughput gene sequencing technology引用本文复制引用
出版年
2024
NETL
NSTL
万方数据