医师在线2025，Vol.15Issue(4) ：54-56.

浸润性肺腺癌EGFR基因突变类型和危险因素研究

Study on EGFR gene mutation types and risk factors in invasive lung adenocarcinoma

吴栋 罗钦辉 劳良玲 吴琴 彭游 陈捷 林立尧
医师在线2025，Vol.15Issue(4) ：54-56.
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  • NSTL
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浸润性肺腺癌EGFR基因突变类型和危险因素研究

Study on EGFR gene mutation types and risk factors in invasive lung adenocarcinoma

吴栋 1罗钦辉 1劳良玲 1吴琴 1彭游 1陈捷 1林立尧1
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作者信息

  • 1. 广东医科大学附属医院胸外科,广东 湛江 524001
  • 折叠

摘要

目的 探讨浸润性肺腺癌表皮生长因子受体(EGFR)基因突变类型和危险因素.方法 回顾性分析2022年7月～2024年6月在广东医科大学附属医院接受手术治疗且病理证实为浸润性肺腺癌并进行EGFR基因突变检测的240例患者的临床资料,分析EGFR基因的突变类型,采用多因素Logistic回归分析浸润性肺腺癌EGFR基因突变的危险因素.结果 EGFR基因突变的发生率为55.00%(132例),其中,EGFR基因21外显子L858R突变、19外显子突变及其他位点突变的构成比分别为56.82%(75例)、32.58%(43例)、10.60%(14例).术前血清癌胚抗原(CEA)＞5 ng/ml、侵犯胸膜、TNM分期为Ⅲ～Ⅳ期、腺泡型肺腺癌是EGFR基因突变的独立危险因素(P＜0.05).结论 浸润性肺腺癌EGFR基因突变以21外显子L858R突变最为常见,术前血清CEA＞5 ng/ml、侵犯胸膜、TNM分期为Ⅲ～Ⅳ期、腺泡型肺腺癌是浸润性肺腺癌EGFR基因突变的独立危险因素.

Abstract

Objective To investigate the mutation types and risk factors of epithelial growth factor receptor(EGFR)gene in invasive lung adenocarcinoma.Methods The clinical data of 240 patients who underwent surgical treatment and were pathologically confirmed as invasive lung adenocarcinoma and underwent EGFR gene mutation detection in the Affiliated Hospital of Guangdong Medical University from July 2022 to June 2024 were retrospectively analyzed,the mutation types of EGFR gene were analyzed,and the risk factors of EGFR gene mutations in invasive lung adenocarcinoma were analyzed by multivariate Logistic regression.Results The incidence of EGFR gene mutations was 55.0%(132 cases),among which the composition ratio of EGFR gene exon 21 L858R mutations,exon 19 mutation and other site mutation was 56.82%(75 cases),32.58%(43 cases)and 10.60%(14 cases),respectively.Preoperative serum carcinoembryonic antigen(CEA)>5 ng/ml,pleural invasion,TNM stage Ⅲ～Ⅳ,and acinar type lung adenocarcinoma were independent risk factors for EGFR gene mutations(P<0.05).Conclusion The most common EGFR gene mutations in invasive lung adenocarcinoma was exon 21 L858R mutation.Preoperative serum CEA>5 ng/ml,invasion of pleura,TNM stage Ⅲ～Ⅳ,acinous lung adenocarcinoma were independent risk factors for EGFR gene mutation in invasive lung adenocarcinoma.

关键词

浸润性肺腺癌/表皮生长因子受体/突变类型/危险因素

Key words

Invasive lung adenocarcinoma/Epidermal growth factor receptor/Mutation type/Risk factor

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出版年

2025
医师在线

医师在线

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