吸烟与种植体周围炎龈沟液中IL-17A表达的相关性研究
Correlation between smoking and IL-17A expression in peri-implant sulcus fluid of patients with peri-implantitis
姜涵 1李晶 2刘利军 3刘慧3
作者信息
- 1. 新疆医科大学第一附属医院:牙周黏膜科, 新疆 乌鲁木齐 830011
- 2. 新疆医科大学第一附属医院:口腔修复科, 新疆 乌鲁木齐 830011
- 3. 新疆医科大学第一附属医院:颌面肿瘤外科, 新疆 乌鲁木齐 830011
- 折叠
摘要
目的:研究吸烟对种植体周围龈沟液(PICF)中IL-17A表达的影响.方法:将种植体周围炎患者分为吸烟组和非吸烟组,并将种植体对侧健康天然牙设为对照组.检测牙周临床指标改良牙龈指数(mGI)、改良龈沟出血指数(mSBI)、探诊深度(PD),并根据X线片测定牙槽骨吸收程度(aBL);采集龈沟液,运用ELISA试验检测IL-17A的浓度.结果:吸烟组IL-17A浓度高于其对照组(P<0.05);吸烟对照组IL-17A浓度高于非吸烟对照组(P<0.05);吸烟组IL-17A浓度高于非吸烟组(P<0.05).吸烟组和非吸烟组IL-17A浓度与PICF体积量有正相关性,吸烟组IL-17A浓度与PD、aBL成正相关,与mGI和mSBI成负相关.结论:IL-17A可作为种植体周围炎的标志性炎症因子之一,吸烟可导致IL-17A表达的升高,推测吸烟是引起种植体周围炎的危险因素之一.
Abstract
AIM: To explore the effects of smoking on IL-17A expression in peri-implant sulcus fluid(PISF) of patients with peri-implantitis.METHODS: The patients were divided into smoking group(n=13) and non-smoking group(n=13).Implant site group of the subjects was included into implant group and the contralateral natural teeth group was included into control group.Modified gingival index(mGI),modified sulcus bleeding index(mSBI),probing depth(PD),alveolar bone loss(aBL)were detected,and the gingival sulcus fluid was collected.The concentration of IL-17A was measured by ELISA.RESULTS: In smoking group,the IL-17A concentration in implant group was higher than that in the control group (P<0.05).Both implant sites and contralateral natural teeth had significantly higher expression of IL-17A in smoking group than that in nonsmoking group (P<0.05).In both smoking and nonsmoking groups,IL-17A concentration was positively correlated with PISF volume.Furthermore,IL-17A concentration in smoking group was positively correlated with AL and PD,and negatively correlated with mGI and mSBI.CONCLUSION: Smoking can lead to increased expression of IL-17A,IL-17A can be used as one of inflammatory markers in peri-implantitis.It is speculated that smoking is one of the risk factors of peri-implantitis.
关键词
吸烟/种植体周围炎/白细胞介素17AKey words
smoking/peri-implantitis/interleukin(IL)-17A引用本文复制引用
基金项目
国家自然科学基金(81460439)
新疆医科大学第一附属医院自然科学基金-青年科学基金(2014ZRQN08)
新疆医科大学人文社会科学基金(2015XYDSK11)
出版年
2017
NETL
NSTL
维普
万方数据