不同HbA1c水平2型糖尿病患者牙周炎状况分析
Clinical analysis of periodontitis in type Ⅱ diabetes patients with different hbA1c levels
黄业翔 1方玲 2高瑞华 2李静2
作者信息
- 1. 甘肃省第二人民医院口腔科 甘肃 兰州 730050
- 2. 甘肃省第二人民医院内分泌科 甘肃 兰州 730050
- 折叠
摘要
目的:对比分析不同糖化血红蛋白(HbA1c)水平2型糖尿病患者的血尿酸?龈沟液炎症因子含量与牙周炎的关系?方法:纳入2型糖尿病合并慢性牙周病患者90例,根据 HbA1c水平分为3组(n=30),A组:HbA1c<7.5%;B组:HbA1c在7.5%~9%;C组:HbA1c≥9%?另选血糖?牙周均健康的体检者30例为对照组?对所有受检者均进行血尿酸?龈沟液炎症因子IL-1?TNF-α的检测及牙周状况的检查,并进行统计分析?结果:A?B?C组的血尿酸水平及龈沟液中IL-1?TNF-α含量均高于对照组,随着HbA1c水平的升高,3组患者龈沟液中IL-1?TNF-α含量也逐渐增高,C组>B组>A组(P<0.05);血尿酸水平也有所增加,B?C组高于A组(P<0.05),B组与C组无统计学差异(P>0.05);B?C组PLI?GI?PD以及CAL均高于A组和对照组(P<0.05);A组与对照组差异无统计学意义(P>0.05)?结论:血尿酸及龈沟液中IL-1?TNF-α与2型糖尿病患者牙周炎发生发展密切相关,2型糖尿病患者牙周炎发生率?发生严重程度与HbA1c水平亦相关?当HbA1c≥7.5%时,牙周炎损害的程度均显著增高.
Abstract
AIM:To study the relation of HbA1c,serum uric acid(SUA) and inflammatory factors in gingival crevicular fluid(GCF) with type 2 diabetes and chronic periodontitis.METHODS:90 patientis with type 2 diabetes mellitus and chronic periodontitis were divided into 3 groups (n=30) according to the HbA1c level, group A:HbA1c<7.5%;Group B:HbA1c between 7.5% and 9%;Group C:HbA1c≥ 9%.30 cases of healthy subjects were included in the control group.SUA, IL-1 and TNF-α in GCF and periodontal indexes in all subjects were measured.Data were statisticaly analysed.RESULTS:The content of SUA, IL-1 and TNF-α in group A, B and C was higher than that in control group.The concentration of IL-1 and TNF-α increased with the increase of HbA1c level(groupC>groupB>groupA, P<0.05).The concentration of SUA increased with the increase of HbA1c level (between group A and B or C, P<0.05;between group B and C(P>0.05).PLI, GI, PD and CAL in group B and C were higher than those in group A and the control (P<0.05;between group A and the control P>0.05).CONCLUSION:The increase of SUA and IL-1 and TNF-α in GCF is the important factors for the development and progression of periodontitis in type 2 diabetes mellitus patients.The severity of periodontitis in patients with type 2 diabetes is closely related to HbA1c level.
关键词
2型糖尿病/牙周炎/糖化血红蛋白Key words
type 2 diabetes mellitus/periodontitis/glycosylated hemoglobin引用本文复制引用
出版年
2017
NETL
NSTL
万方数据