摘要
目的:制备PLGA-壳聚糖/大黄素电纺纤维膜,并评价其相关理化性能.方法:分别采用同轴静电纺丝法和传统静电纺丝法(混纺法)制备PLGA-壳聚糖/大黄素电纺纤维膜;扫描电镜观察纤维膜的表面形貌,透射电镜观察纤维的同轴结构,生物力学测试仪测量纤维膜力学的性能,高压液相色谱(HPLC)法测量大黄素的释放率.结果:利用同轴静电纺丝技术制备的同轴PLGA-壳聚糖/大黄素电纺纤维膜的纤维方向随机且直径均匀,纤维表面光滑无串珠;其纤维直径为(927±73)nm,拉伸强度为(4.62±0.58)MPa,弹性模量为(13.73±2.64)MPa,均明显高于混纺组(P<0.05),而大黄素的释放则较混纺组明显变缓(P<0.05),并可持续释放15 d以上.结论:同轴静电纺丝法制备的PLGA-壳聚糖/大黄素电纺纤维膜具有良好的力学性能和药物缓释效果.
Abstract
AIM:To prepare a novel Polylactide (PLA)-chitosan(CS)/emodin nanofibrous membrane and to evaluate the physical and chemical properties of PLA-CS/Emodin.METHODS:Nanofibrous membrane with PLA-CS/Emodin was preparedb by co-electrospinning technology (test group) and traditional electrospinning method (the control group) respectively.Then morphology and coaxial structure was observed by SEM, the mechanical properties and emodin release rate were examined by biomechanic tester and HPLC respectively.RESULTS:The fiber of the test group was uniformly distributed and the surface of fibers was smooth.The diameter was(927±73)nm,and the tensile strength (4.62±0.58)MPa,the elastic modulus(13.73±2.64)MPa, emodin release rate was lower than that of the control(P<0.05)and the release kept for more than 15 d.The mechanical properties of the test group were different from those of the control group.CONCLUSION:The PLA-CS/Emodin fiber presents outstanding mechanical properties and sustained-release properties.
NETL
NSTL
维普
万方数据