信号网络在牙齿发育中的作用
The role of signaling network in tooth development
刘皓1
作者信息
摘要
转录因子Msx2、Runx2可通过Smad信号通路和p38 MAPK信号通路对成釉细胞合成外基质起重要作用;FGFs能直接调控Msxs的表达并参与Smad信号通路,也能通过参与活化MEK-ERK信号通路间接下调Smads转录活性,从而达到调控Smad信号通路的目的;Pitx2可通过Nodal/Sonic hedghog信号通路影响牙胚分化及外基质的合成;转录因子Msx2能通过Smad信号通路和Wnt信号通路影响釉基质的分泌,说明Msx2作为两种信号通路的交叉点在牙齿发育过程中是不可缺少的.本文就Msx2、Runx2、FGF2、Bmp、Pitx2等转录因子通过多种信号通路的相互调控对牙齿发育的影响作一综述.
Abstract
Transcription factors Msx2 and Runx2 play an important role in the extracellular matricx synthesis of emailloblasts through the Smad signaling pathway and the p38 MAPK signaling pathway.FGFs can participate in Smad signaling pathway and regulate the expression of Maxs directly,can also participate in the activation of MEK-ERK signaling pathway to down-regulate Smads transcriptional activity,therefore regulat Smad signaling pathway.Pitx2 can regulare the dental germ differentiation and the extracellular matrix synthesis through Nodal/Sonic hedghog signaling pathway.Transcription factor Msx2 effects enamel matrix secretion through Smad signaling pathway and Wnt signaling pathway.All of these indicate that Msx2 is of great significance as the intersection of the two kinds of signaling pathways in the dental development process.In this paper,the effects of transcription factors such as Msx2,Runx2,FGF2,Bmp and Pitx2 on dental development through a variety of signaling pathways were reviewed.
关键词
牙齿发育/Smad信号通路/FGF2/Msx2Key words
tooth development/smad signaling pathway/FGF2/Msx2引用本文复制引用
基金项目
国家自然科学基金(81441107)
山东省自然科学基金(ZR2017MH103)
山东省高等学校科技计划项目(J15LK09)
出版年
2017
NETL
NSTL
维普
万方数据