Re-recognition of the role of Enterococcus faecalis in secondary root canal infection
The anatomical complexity of the root canal system and the persistence of microbes within the root canal system often lead to the reinfection,resulting in the failure of root canal therapy and poor prognosis of affect-ed teeth.Enterococcus faecalis(Ef)is the key pathogenic bacterium in secondary root canal infection,and is involved in the development of secondary root canal infection and apical periodontitis by forming biofilms that are difficult to remove and secreting a variety of virulence factors.For the past decades,extensive studies on the pathogenic mechanism and intervention measures of Efini secondary root canal infection have been conducted,and researchers have recognized that besides Ef,various microorganisms also play an important role in secondary root canal infection.Therefore,understand-ing the interactions between these key microorganisms helps to better understand the possible etiology of secondary root canal infection.Ef has gone from being"recognized"for its high detection rate to being"questioned"and"re-recog-nized"as a variety of microorganisms have been detected with the development of the technology and further study.This article aims to discuss the important role of microorganisms dominated by Ef and to further understand the crucial role of Efin secondary root canal infection.
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