Effect of sipayi gingival fluid combined with minocycline on periodontal basic treatment in patients with localized invasive periodontitis
AIM:To investigate the clinical effect of sipayi gingival stabilization solution combined with mino-cycline in the treatment of localized aggressive periodontitis(LIP)and its effect on the recurrence rate.METHODS:142 LIP patients in our hospital from February 2017 to October 2017 were selected.They were divided into observation group(47 cases),control group(43 cases)and normal group(52 cases).The normal group received routine periodontal treatment.Control group was treated with sipayi gingival fluid on the basis of normal group.The observation group was treated with 2％minocycline hydrochloride ointment on the basis of the control group on the basis of periodontal probing depth of more than 5 mm.The effects of the three groups were observed,and the changes of SBI,PD,PLI,CAL,serum CRP,TNF-at,IL-17 levels,bone resorption and bone mineral density were observed before and after treatment.RESULTS:The total effec-tive rate of observation group was higher than that of control group and normal group(P＜0.05).After treatment,the serum levels of CRP,TNF-α and IL-17 in three groups were decreased(P＜0.05).PLI,SBI,PD and CAL were decreased(P＜0.05);Bone absorption decreased and bone mineral density increased in the three groups(P＜0.05).There was no differ-ence in recurrence rate among the three groups(P＞0.05).CONCLUSION:Sipayi gingival fluid combined with minocy-cline has a significant effect on LIP treatment,and there is no difference in recurrence rate.
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