Effects of initial therapy combined with hyaluronic acid gel on masticatory function and levels of LF and dickkopf-l in gingival crevicular fluid in patients with chronic periodontitis
AIM:The aim of this study is to investigate the effects of periodontal basic treatment combined with hyaluronic acid gel on masticatory function and the levels of lactoferrin(LF)and Dickkopf-l in gingival crevicular fluid in patients with chronic periodontitis(CP).METHODS:145 patients with CP treated in our hospital from January 2022 to June 2023 were divided into observation group(n=73)and control group(n=72)according to the random number table method.The control group was treated with periodontal basic treatment,and the observation group was treated with hyaluronic acid gel on the basis of the control group.The clinical efficacy,masticatory function,LF,Dickkopf-l,periodontal parameters and adverse reactions were compared between the two groups.RESULTS:The total effective rate of the observation group was higher than that of the control group,the masticatory efficiency after treatment was higher than that of the control group,the levels of LF and Dickkopf-l were lower than those of the control group,and the periodontal pocket depth(PD),gingival bleeding index(BI)and plaque index(PLI)were lower than those of the control group after treatment,with statistical differences(P<0.05);In terms of adverse reactions,there was no statistical difference between the two groups(P＞0.05).CONCLUSION:Initial therapy combined with hyaluronic acid gel in the treatment of CP can improve the masticatory function and periodontal parameters,reduce the levels of LF and Dickkopf-l in gingival crevicular fluid,and the adverse reactions do not increase.
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