Research progress on the impact of bile acids on the health of periodontal tissues
Periodontitis is a common chronic infectious disease in the oral cavity,which can cause significant destruction of periodontal supporting tissues and tooth loss.The health of periodontal tissues not only affects the health of multiple systems throughout the body,but is also regulated by various systemic diseases.Bile acids are an important class of compounds synthesized by the liver and excreted into the small intestine in the form of bile.They not only participate in the absorption of lipids and fat-soluble vitamins,but also activate multiple nuclear receptor and membrane receptor-mediated signaling pathways to participate in the fine regulation of glucose and lipid metabolism.Additionally,can affect the composition of the intestinal microbiota and the synthesis and secretion of certain hormones.Imbalances in metabolism and abnormal signal transmission have been shown to be closely related to various systemic diseases.However,current research on the impact of bile acids on periodontal tissue health is still relatively superficial.This review first summarizes the types and basic characteristics of bile acids and further analyzes their impact on various systemic diseases closely related to periodontitis.Simultaneously,it delves into the direct impact of bile acids on factors that affect periodontal health,such as bone metabolism,immune cells,and oral microbiota,to explore potential mechanisms and intervention targets for the effect of bile acids on periodontal tissue health.This review aims to provide a useful theoretical basis and solid foundation for the diagnosis,treatment,and management of clinical periodontitis diseases.
bile acidsperiodontal tissuesystemic diseasesinflammation
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