首页|头颈部肿瘤放疗的口腔剂量学与放射龋的相关性研究

头颈部肿瘤放疗的口腔剂量学与放射龋的相关性研究

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目的:研究头颈部肿瘤(HNC)放疗患者口腔内主要器官的放疗剂量分布特点及放射龋(RC)与放疗剂量的关系.方法:回顾性评估40例HNC放疗患者,根据肿瘤类型分为鼻咽癌组、口腔癌组、口咽癌组、下咽癌组(n=10),用放疗计划系统记录口腔内主要器官的Dmax和Dmean.结果:在4组中,牙齿Dmax、Dmean值均依次为磨牙>前磨牙>前牙;除鼻咽癌组外,其余3组下颌牙平均Dmax、Dmean均高于上颌牙;除下咽癌组外,其余3组牙齿Dmax、Dmean与肿瘤部位(左右侧)的关系均有统计学意义(P<0.05),肿瘤同侧牙齿Dmax、Dmean高于肿瘤对侧;除下咽癌组牙齿Dmax外,下咽癌组牙齿Dmean和其余3组牙齿Dmax、Dmean与是否患RC无统计学意义(P>0.05).结论:相比之下,磨牙、下颌牙和肿瘤同侧牙齿会暴露于更高剂量的辐射之中,应对此类牙齿施以针对性的保护措施;且牙齿剂量不是决定RC是否发生的独立因素.
Study on oral dosimetry of radiotherapy for head and neck cancer and its correlation with radiation caries
AIM:To study the dose distribution characteristics of the main organs in the oral cavity of patients with head and neck cancer(HNC)radiotherapy and the relationship between radiation caries(RC)and radiotherapy dose.METHODS:Forty patients with HNC were retrospectively evaluated.According to the type of tumor,they were divided into nasopharyngeal carcinoma group,oral cancer group,oropharyngeal cancer group and hypopharyngeal cancer group(n=10).The Dmax and Dmean of the main organs in the oral cavity were recorded by the radiotherapy planning system.RESULTS:In the four groups,the Dmax and Dmean values of teeth were in the order of molars>premolars>anterior teeth.Except for nasopharyngeal carcinoma group,the Dmax and Dmean of mandibular teeth in the other three groups were higher than those of maxillary teeth.Except for hypopharyngeal carcinoma group,the relationship between Dmax,Dmean and tumor location(according to the laterality)in the other three groups was statistically significant(P<0.05).CONCLUSION:In contrast,molars,mandibular teeth and teeth on the same side of the tumor will be exposed to higher doses of radiation,and targeted protective measures should be taken for such teeth.Tooth dose is not an independent factor in determining whether RC occurs.

head and neck cancerradiation doseradiation caries

曾琛琛、叶丽君、周卫兵、周新春、王思琪、龚星、陈其田

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湖北医药学院附属襄阳市第一人民医院口腔科 湖北襄阳 441000

湖北医药学院附属襄阳市第一人民医院肿瘤科 湖北襄阳 441000

头颈部肿瘤 放疗剂量 放射龋

2022年度医疗卫生领域科技重点项目

2022YL37A

2024

牙体牙髓牙周病学杂志
第四军医大学口腔医学院

牙体牙髓牙周病学杂志

影响因子:0.946
ISSN:1005-2593
年,卷(期):2024.29(9)
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