牙髓干细胞的免疫调节功能与临床应用前景
Immunomodulatory property of dental pulp stem cells and their prospects in clinical applications
轩昆 1王曼雨 1刘安琪2
作者信息
- 1. 口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院预防科,陕西西安 710032
- 2. 口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院预防科,陕西西安 710032;中国人民解放军联勤保障部队第九八五医院口腔科,山西太原 030000
- 折叠
摘要
牙髓干细胞(DPSCs)在免疫治疗和临床转化应用中发挥越来越重要的作用,其优越的免疫调节和抗炎特性为免疫治疗提供可能.本文从DPSCs免疫调控的角度,结合最新的单细胞转录组测序结果,总结DPSCs重塑免疫微环境,治疗免疫相关疾病的作用机制,并汇总了 2016年至2024年DPSCs用于全身系统性疾病治疗的注册临床试验,为从单细胞水平深入解析DPSCs的免疫调节功能和临床转化应用提供参考.
Abstract
Dental pulp stem cells(DPSCs)are increasingly recognized for their pivotal role in immunotherapy and clinical translation.Their exceptional immunomodulatory and anti-inflammatory capabilities make them promising candidates for immunotherapeutic strategies.This review integrates recent single-cell RNA sequencing data to elucidate the mechanisms by which DPSCs modulate the immune microenvironment and ameliorate immune-related diseases.Additionally,it compiles a comprehensive list of clinical trials registered from 2016 to 2024 that utilize DPSCs for the treatment of systemic diseases,provide insights into the immunomodulatory functions of DPSCs at the single-cell level and their potential for clinical application.
关键词
牙髓干细胞/乳牙牙髓干细胞/免疫调节/免疫治疗/单细胞转录组测序Key words
dental pulp stem cells/stem cells from human exfoliated deciduous teeth/immunomodulation/immunotherapy/single-cell RNA sequencing引用本文复制引用
出版年
2024
NETL
NSTL
万方数据