聚乙二醇基水凝胶促进口腔溃疡愈合的研究
Study on polyethylene glycol-based hydrogel for promoting the healing of oral ulcers
林华俊 1陈路沅 2隋文 3陈智慧 2赵婷婷 4余诚诚 5段咏华 6洪咏龙7
作者信息
- 1. 南方医科大学深圳医院颌面外科,广东 深圳 518000;南方医科大学口腔医学院,广东 广州 510000;上饶市人民医院口腔科,江西上饶 334000
- 2. 南方医科大学深圳医院口腔诊疗中心,广东 深圳 518000
- 3. 深圳技术大学口腔学院,广东 深圳 518000
- 4. 南方医科大学深圳医院颌面外科,广东 深圳 518000
- 5. 南方医科大学深圳口腔医院(坪山),广东 深圳 518118
- 6. 上饶市人民医院口腔科,江西上饶 334000
- 7. 南方医科大学深圳医院颌面外科,广东 深圳 518000;南方医科大学口腔医学院,广东 广州 510000
- 折叠
摘要
目的:制备负载醋酸地塞米松的聚乙二醇基水凝胶,同时初步探究该体系对口腔溃疡的疗效.方法:利用氨解反应制备水凝胶,分析该水凝胶物理性能;使用人牙龈成纤维细胞通过CCK-8法及细胞活死染色评价水凝胶的生物相容性;通过体内口腔溃疡模型评价溃疡创面修复效果.结果:水凝胶具有良好的生物安全性,体内、体外实验均证实其优秀的粘接性能及机械强度,可促进口腔溃疡创面的愈合.结论:制备的水凝胶可提高口腔溃疡创面的修复效能,有望成为治疗口腔溃疡的新型材料.
Abstract
AIM:To prepare polyethylene glycol-based hydrogels loaded with dexamethasone acetate and initially explore the efficacy of this system in treating oral ulcers.METHODS:The hydrogels were prepared using aminolysis reaction,and its physical properties were analyzed.The biocompatibility of the hydrogels was evaluated using human gingival fibroblasts through the CCK-8 method and cell viability/death staining.The repair effect of ulcer wounds was evaluated through an in vivo oral ulcer model.RESULTS:The hydrogels exhibited good biosafety,excellent adhesive properties,and mechanical strength both in vitro and in vivo,which could promote the healing of oral ulcer wounds.CONCLUSION:The prepared hydrogels can improve the repair efficacy of oral ulcer wounds and are expected to become a novel material for treating oral ulcers.
关键词
口腔溃疡/生物相容性/聚乙二醇/地塞米松/软组织修复Key words
oral ulcer/biocompatibility/polyethylene glycol/dexamethasone/soft tissue repair引用本文复制引用
出版年
2024
NETL
NSTL
万方数据