糖皮质激素联合氟康痤胶囊治疗小儿重症哮喘合并口腔真菌感染急性发作期患者的回顾性分析研究
Retrospective analysis of corticosteroids combined with fluconacne capsules in children with severe asthma combined with acute onset of oral fungal infection
林婷婷 1夏美玲 1周英 1钱萍2
作者信息
- 1. 浙江杭州 浙江中医药大学附属江南医院,311201
- 2. 浙江杭州 杭州师范大学附属医院,311200
- 折叠
摘要
目的:糖皮质激素联合氟康痤胶囊对重症哮喘合并口腔真菌感染急性发作期患者肺功能、脑钠尿肽(BNP)、嗜酸性粒细胞(EOS)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、口腔及与骨膜蛋白水平的Logistic回归分析.方法:选取浙江中医药大学附属江南医院2021年4月至2022年8月收治的小儿重症哮喘合并口腔真菌感染急性发作期142例患儿进行回顾性分析.根据治疗方法,将予口服泼尼松龙治疗的划为对照组,口服泼尼松龙治疗+氟康唑胶囊干预的划为观察组,各48例.比较两组患者肺功能口腔愈合时间等因素差异.结果:治疗后,观察组患者炎症因子、肺功能指标浓度明显优于对照组患者(P＜0.05).其中年龄与患儿急性发作期治疗效果呈正相关(P＜0.05),而合并下呼吸道感染与骨膜蛋白水平呈负相关(P＜0.05).结论:糖皮质激素联合氟康痤胶囊可以有效的调节患儿肺功能.另外,年龄、骨膜蛋白水平与合并下呼吸道感染是影响患儿转归的独立危险因素.
Abstract
AIM:TLogistic regression analysis of corticosteroids combined with fluacne capsules on lung function,brain natriuresis peptide(BNP),eosinophils(EOS),interleukin-4(IL-4),interleukin-6(IL-6),oral cavity and periostin levels in patients with severe asthma with oral fungal infection.METHODS:A total of 142 children with severe asthma and oral fungal infection in Jiangnan Hospital Affilated to Zhejiang Chinese Medical University from April 2021 to August 2022 were selected for retrospective analysis.According to the treatment method,those treated with oral prednisolone were classified as the control group,and those treated with oral prednisolone treatment+fluconazole capsule intervention were classified as the observation group,48 cases each.Compcompare factors such as duration of lung function between the two groups.RESULTS:After treatment,the concentration of inflammatory factors and pulmonary function indicators in the observation group was significantly better than that in the control group(P＜0.05).Among them,age was positively correlated with the treatment effect during acute onset(P＜0.05),while lower respiratory tract infection was negatively correlated with periosteal protein level(P＜0.05).CONCLUSION:Glucocorticoid combined with fluconacne capsule can effectively regulate the lung function in children.In addition,age,periostin level and combined lower respiratory tract infection are independent risk factors affecting the outcome of children.
关键词
Logistic线性回归分析模型/小儿支气管哮喘急性发作期/口腔真菌感染/炎性因子/骨膜蛋白水平Key words
Logistic linear regression analysis model/neonatal jaundice/oral fungal infection/inflammatory factors/periosteal protein levels引用本文复制引用
出版年
2024
NETL
NSTL
万方数据