药物不良反应杂志2013,Vol.15Issue(3) :174-175.DOI:10.3760/cma.j.issn.1008-5734.2013.03.020

复方甘草片致低钾血症

Compound licorice tablets-induced hypokalemia

张路 吴庆军 茅江峰
药物不良反应杂志2013,Vol.15Issue(3) :174-175.DOI:10.3760/cma.j.issn.1008-5734.2013.03.020

复方甘草片致低钾血症

Compound licorice tablets-induced hypokalemia

张路 1吴庆军 2茅江峰3
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作者信息

  • 1. 100032 中国医学科学院北京协和医学院北京协和医院内科
  • 2. 100032 中国医学科学院北京协和医学院北京协和医院风湿免疫科
  • 3. 100032 中国医学科学院北京协和医学院北京协和医院内分泌科
  • 折叠

摘要

1例69岁女性患者因反复咳嗽、咳痰4个月、乏力1个月入院.电解质检查示血钾2.4 mmol/L;心电图检查示T波低平,T波与U波融合,按心率校正的QT (QTc)间期468 ms.诊断为低钾血症,给予补钾治疗2d,血钾为3.2 ~ 3.3 mmol/L.追问病史得知患者因咳嗽自行服用复方甘草片已2个月,总量超过500片.停用复方甘草片,继续给予补钾治疗,次日患者血钾即升至4.4 mmol/L,乏力症状缓解,心电图检查示T波及QTc间期恢复.停用复方甘草片3d后停用补钾药物,患者血钾维持在3.6 ~ 3.9 mmol/L.随访3个月,患者血钾未再出现异常.

Abstract

A 69-year-old woman was hospitalized because of repeated cough and cough up phlegm for 4 months and fatigue for one month.The electrolyte analysis revealed a potassium level of 2.4 mmol/L and an electrocardiogram showed flat T waves,fusion of T and U waves,and the heart rate-corrected QT (QTc) interval of 468 ms.Hypokalemia was diagnosed.Potassium supplement treatment was given.However,the potassium level was 3.2-3.3 mmol/L after 2 days of treatment.A careful history taking revealed that the patient had been taking compound licorice tablets by herself for cough for more than 2 months (a total of more than 500 tablets).The compound licorice tablets were stopped and potassium supplement was given continuously.The next day,the patient's potassium level increased to 4.4 mmol/L and her fatigue relieved.An electrocardiogram showed normalization of T waves and QTc interval.After 3 days of discontinuation of compound licorice tablets,the potassium supplement treatment was stopped.The patient's potassium level remained 3.6-3.9 mmol/L.Abnormal potassium level did not recur during the 3 months of follow-up.

关键词

甘草/低钾血症

Key words

Glycyrrhiza uralensis/Hypokalemia

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出版年

2013
药物不良反应杂志
中华医学会

药物不良反应杂志

CSTPCDCSCD
影响因子:0.667
ISSN:1008-5734
被引量9
参考文献量6
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