对乙酰氨基酚（APAP）是目前临床使用最广泛的解热镇痛药，常规剂量安全可靠，长期大量用药会导致重要器官损伤。近年来对APAP的安全性问题有一些新发现，如APAP可使高血压患者血压升高，含钠APAP与心血管疾病风险和全因死亡率增加相关，新发现多种预测、诊断APAP相关肝损伤及其预后的生物标志物，APAP可导致肾损伤风险增加等。APAP相关重要器官损伤的安全防范策略包括严格限制用药剂量和疗程、关注特殊人群用药安全等；对于已出现重要器官损伤的患者，应对其因果关系进行评价、及时停药、给予特异性治疗和对症支持治疗。 Acetaminophen is currently the most widely used antipyretic analgesics in clinical practice。 The conventional dose of acetaminophen is safe and reliable， and long-term use in large quantities can cause damage to important organs。 In recent years， some new safety issues of acetaminophen have been found， such as its possibility to increase blood pressure in patients with hypertension， its association with increased risk of cardiovascular disease and all-cause mortality with sodium-containing acetaminophen， the discovery of multiple biomarkers for predicting and diagnosing acetaminophen-related liver injury and its prognosis， and its possibility to increase the risk of kidney injury。 The safety prevention strategies for important organ injuries related to acetaminophen include strict restrictions on medication dosage and duration， and attention to medication safety for special populations。 For patients who have experienced significant organ damages， their causal relationship should be evaluated， acetaminophen should be stopped， and specific treatment， and symptomatic and supportive treatments should be provided。
Pay attention to the prevention and supervision of important organ damage related to acetaminophen
Acetaminophen is currently the most widely used antipyretic analgesics in clinical practice. The conventional dose of acetaminophen is safe and reliable, and long-term use in large quantities can cause damage to important organs. In recent years, some new safety issues of acetaminophen have been found, such as its possibility to increase blood pressure in patients with hypertension, its association with increased risk of cardiovascular disease and all-cause mortality with sodium-containing acetaminophen, the discovery of multiple biomarkers for predicting and diagnosing acetaminophen-related liver injury and its prognosis, and its possibility to increase the risk of kidney injury. The safety prevention strategies for important organ injuries related to acetaminophen include strict restrictions on medication dosage and duration, and attention to medication safety for special populations. For patients who have experienced significant organ damages, their causal relationship should be evaluated, acetaminophen should be stopped, and specific treatment, and symptomatic and supportive treatments should be provided.
AcetaminophenDrug-related side effects and adverse reactionsChemical and drug induced liver injuryCardiotoxicityAcute kidney injurySafety management
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