首页|Lipid metabolism analysis in esophageal cancer and associated drug discovery

Lipid metabolism analysis in esophageal cancer and associated drug discovery

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Esophageal cancer is an upper gastrointestinal malignancy with a bleak prognosis.It is still being explored in depth due to its complex molecular mechanisms of occurrence and development.Lipids play a crucial role in cells by participating in energy supply,biofilm formation,and signal transduction pro-cesses,and lipid metabolic reprogramming also constitutes a significant characteristic of malignant tu-mors.More and more studies have found esophageal cancer has obvious lipid metabolism abnormalities throughout its beginning,progress,and treatment resistance.The inhibition of tumor growth and the enhancement of antitumor therapy efficacy can be achieved through the regulation of lipid metabolism.Therefore,we reviewed and analyzed the research results and latest findings for lipid metabolism and associated analysis techniques in esophageal cancer,and comprehensively proved the value of lipid metabolic reprogramming in the evolution and treatment resistance of esophageal cancer,as well as its significance in exploring potential therapeutic targets and biomarkers.

Lipid metabolismEsophageal cancerProgressionTreatment resistanceNew therapeutic targets

Ruidi Jiao、Wei Jiang、Kunpeng Xu、Qian Luo、Luhua Wang、Chao Zhao

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Bionic Sensing and Intelligence Center,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,518000,China

Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen,Guangdong,518116,China

School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,5180

University of Chinese Academy of Sciences,Beijing,100049,China

School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518000,China

Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,518000,China

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国家自然科学基金国家自然科学基金国家重点研发计划Shenzhen Key Laboratory of Precision Diagnosis and Treatment of DepressionGuangdong Province Zhu Jiang Talents Plan,China广东省自然科学基金Key Program of Fundamental Research in Shenzhen,ChinaSustainable Development Program of Shenzhen,ChinaNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical College,ShenzhenChinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen

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2024

10.1016/j.jpha.2023.08.019

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(1)
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