首页|A proteomic landscape of pharmacologic perturbations for functional relevance

A proteomic landscape of pharmacologic perturbations for functional relevance

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  • 国家科技期刊平台
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  • NSTL
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Pharmacological perturbation studies based on protein-level signatures are fundamental for drug dis-covery.In the present study,we used a mass spectrometry(MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds.The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells.Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol,as well as the noncanonical targets of clinically approved tamoxifen,lovastatin,and their derivatives.Furthermore,the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints.This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

ProteomicsDrugPerturbationDrug targetDrug combination

Zhiwei Liu、Shangwen Jiang、Bingbing Hao、Shuyu Xie、Yingluo Liu、Yuqi Huang、Heng Xu、Cheng Luo、Min Huang、Minjia Tan、Jun-Yu Xu

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State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China

School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing,210023,China

Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan,Guangdong,528400,China

State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing,210023,China

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国家自然科学基金国家自然科学基金国家重点研发计划Shanghai Academic/Technology Research Leader Program,ChinaGuangdong High-level New Research and Development Institute,ChinaGuangdong High-level Innovative Research Institute,China上海市青年科技启明星计划中国科学院青年创新促进会项目Young Elite Scientists Sponsorship Program by China Association for Science and Technology,Chinaopen fund of State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,ChinaInnovative Research Team of High-Level Local Universities in Shanghai,ChinaSanofi scholarship program

22225702323220482020YFE020220022XD14209002019B0909040082021B090905000322QA141110020212762022QNRC001KF-202201SHSMU-ZDCX20212700

2024

10.1016/j.jpha.2023.08.021

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(1)
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