首页|The potential of herbal drugs to treat heart failure:The roles of Sirt1/AMPK

The potential of herbal drugs to treat heart failure:The roles of Sirt1/AMPK

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Heart failure(HF)is a highly morbid syndrome that seriously affects the physical and mental health of patients and generates an enormous socio-economic burden.In addition to cardiac myocyte oxidative stress and apoptosis,which are considered mechanisms for the development of HF,alterations in cardiac energy metabolism and pathological autophagy also contribute to cardiac abnormalities and ultimately HF.Silent information regulator 1(Sirt1)and adenosine monophosphate-activated protein kinase(AMPK)are nicotinamide adenine dinucleotide(NAD+)-dependent deacetylases and phosphorylated kinases,respectively.They play similar roles in regulating some pathological processes of the heart through regulating targets such as peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α),protein 38 mitogen-activated protein kinase(p38 MAPK),peroxisome proliferator-activated receptors(PPARs),and mammalian target of rapamycin(mTOR).We summarized the synergistic effects of Sirt1 and AMPK in the heart,and listed the traditional Chinese medicine(TCM)that exhibit cardioprotective properties by modulating the Sirt1/AMPK pathway,to provide a basis for the development of Sirt1/AMPK activators or inhibitors for the treatment of HF and other cardiovascular diseases(CVDs).

Heart failureSilent information regulator 1Adenosine monophosphate-activated protein kinaseTraditional Chinese medicine

Tao Zhang、Lei Xu、Xiaowei Guo、Honglin Tao、Yue Liu、Xianfeng Liu、Yi Zhang、Xianli Meng

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State Key Laboratory of Southwestern Chinese Medicine Resources,Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China

College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China

School of Ethnic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China

Meishan Hospital of Chengdu University of Traditional Chinese Medicine,Meishan,Sichuan,620032,China

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国家自然科学基金the"Xinglin Scholars"Research Promotion Program of Chengdu University of Traditional Chinese Medicine中国博士后科学基金Science Foundation for Youths of Science and Technology Department of Sichuan Province

82130113ZDZX20220052021MD7038002022NSFSC1449

2024

10.1016/j.jpha.2023.09.001

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(2)
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