首页|Targeting the chromatin structural changes of antitumor immunity

Targeting the chromatin structural changes of antitumor immunity

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of cancer.Although defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their combinations.Herein,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research methods.We emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

Antitumor immunityChromatin structuralCancer epigeneticsDNA methylationHistone modificationChemotherapy

Nian-nian Li、Deng-xing Lun、Ningning Gong、Gang Meng、Xin-ying Du、He Wang、Xiangxiang Bao、Xin-yang Li、Ji-wu Song、Kewei Hu、Lala Li、Si-ying Li、Wenbo Liu、Wanping Zhu、Yunlong Zhang、Jikai Li、Ting Yao、Leming Mou、Xiaoqing Han、Furong Hao、Yongcheng Hu、Lin Liu、Hongguang Zhu、Yuyun Wu、Bin Liu

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Weifang People's Hospital,Weifang,Shandong,261000,China

School of Life Sciences,Nankai University,Tianjin,300071,China

Weifang Traditional Chinese Medicine Hospital,Weifang,Shandong,261000,China

Shaanxi Key Laboratory of Sericulture,Ankang University,Ankang,Shaanxi,725000,China

Guizhou Education University,Guiyang,550018,China

Guizhou Normal University,Guiyang,550025,China

School of Medical Imaging,Weifang Medical University,Weifang,Shandong,261053,China

Department of Bone and Soft Tissue Oncology,Tianjin Hospital,Tianjin,300299,China

Teda Institute of Biological Sciences & Biotechnology,Nankai University,Tianjin,300457,China

Xinqiao Hospital of Army Military Medical University,Chongqing,400038,China

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Startup Foundation for Junior Faculty,Nankai UniversityNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaHealth Commission Foundation of ChinaChongqing Medical College Natural FundChongqing Medical College Natural Fund

631914393210041832100403452018ZX10712001-017ygz2019302ygz2019305

2024

10.1016/j.jpha.2023.11.012

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(4)
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