首页|An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke

An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke

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  • 国家科技期刊平台
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A two-photon near infrared(NIR)fluorescence turn-on sensor with high selectivity and sensitivity for Zn2+detection has been developed.This sensor exhibits a large Stokes'shift(-300 nm)and can be excited from 900 to 1000 nm,with an emission wavelength of-785 nm,making it ideal for imaging in biological tissues.The sensor's high selectivity for Zn2+over other structurally similar cations,such as Cd2+,makes it a promising tool for monitoring zinc ion levels in biological systems.Given the high concentration of zinc in thrombi,this sensor could provide a useful tool for in vivo thrombus imaging.

Near-infraredMolecular imagingThrombusStroke

Junfeng Wang、Qibing Liu、Yingbo Li、Yi Pang

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Department of Chemistry,The University of Akron,Akron,OH 44325,USA

Gordon Center for Medical Imaging,Department of Radiology,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02114,USA

Department of Pharmacy,The First Affiliated Hospital of Hainan Medical University,Haikou,570100,China

Engineering Research Center of Tropical Medicine,Ministry of Education,Hainan Medical University,Haikou,571199,China

State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,100191,China

Maurice Morton Institute of Polymer Science,The University of Akron,Akron,OH 44325,USA

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National Institute of HealthNational Institute of Health

1R15EB014546-01A1K25AG061282

2024

10.1016/j.jpha.2023.11.010

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(4)
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