首页|Model informed precision medicine of Chinese herbal medicines formulas-A multi-scale mechanistic intelligent model

Model informed precision medicine of Chinese herbal medicines formulas-A multi-scale mechanistic intelligent model

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Recent trends suggest that Chinese herbal medicine formulas(CHM formulas)are promising treatments for complex diseases.To characterize the precise syndromes,precise diseases and precise targets of the precise targets between complex diseases and CHM formulas,we developed an artificial intelligence-based quantitative predictive algorithm(DeepTCM).DeepTCM has gone through multilevel model cali-bration and validation against a comprehensive set of herb and disease data so that it accurately captures the complex cellular signaling,molecular and theoretical levels of traditional Chinese medicine(TCM).As an example,our model simulated the optimal CHM formulas for the treatment of coronary heart disease(CHD)with depression,and through model sensitivity analysis,we calculated the balanced scoring of the formulas.Furthermore,we constructed a biological knowledge graph representing interactions by associating herb-target and gene-disease interactions.Finally,we experimentally confirmed the thera-peutic effect and pharmacological mechanism of a novel model-predicted intervention in humans and mice.This novel multiscale model opened up a new avenue to combine"disease syndrome"and"macro micro"system modeling to facilitate translational research in CHM formulas.

Chinese herbal medicine formulasPrecision medicineMathematical modelingSystems biologyCoronary heart diseaseDepressionIschemia-reperfusionInflammation

Yuanyuan Qian、Xiting Wang、Lulu Cai、Jiangxue Han、Zhu Huang、Yahui Lou、Bingyue Zhang、Yanjie Wang、Xiaoning Sun、Yan Zhang、Aisong Zhu

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Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome,Zhejiang Chinese Medical University,Hangzhou,310000,China

Zhejiang Engineering Research Center for"Preventive Treatment"Smart Health of Traditional Chinese Medicine,Zhejiang Chinese Medical University,Hangzhou,310000,China

College of Basic Medical Sciences,Zhejiang Chinese Medical University,Hangzhou,310000,China

Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing,100190,China

Academy of Chinese Medical Science,Zhejiang Chinese Medical University,Hangzhou,310000,China

Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang,110032,China

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National Natural Science Foundation of ChinaNational Key R&D Program of ChinaPostdoctoral Innovation Talent Support Program

821742462019YFC1708701BX20220329

2024

10.1016/j.jpha.2023.12.004

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(4)
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