首页|Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis

Apatinib and gamabufotalin co-loaded lipid/Prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis

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Due to the non-targeted release and low solubility of anti-gastric cancer agent,apatinib(Apa),a first-line drug with long-term usage in a high dosage often induces multi-drug resistance and causes serious side effects.In order to avoid these drawbacks,lipid-film-coated Prussian blue nanoparticles(PB NPs)with hyaluronan(HA)modification was used for Apa loading to improve its solubility and targeting ability.Furthermore,anti-tumor compound of gamabufotalin(CS-6)was selected as a partner of Apa with reducing dosage for combinational gastric therapy.Thus,HA-Apa-Lip@PB-CS-6 NPs were constructed to synchro-nously transport the two drugs into tumor tissue.In vitro assay indicated that HA-Apa-Lip@PB-CS-6 NPs can synergistically inhibit proliferation and invasion/metastasis of BGC-823 cells via downregulating vascular endothelial growth factor receptor(VEGFR)and matrix metalloproteinase-9(MMP-9).In vivo assay demonstrated strongest anti-tumor growth and liver metastasis of HA-Apa-Lip@PB-CS-6 NPs adminis-tration in BGC-823 cells-bearing mice compared with other groups due to the excellent penetration in tumor tissues and outstanding synergistic effects.In summary,we have successfully developed a new nanocomplexes for synchronous Apa/CS-6 delivery and synergistic gastric cancer(GC)therapy.

ApatinibGamabufotalinLipid/Prussian blue nanoparticlesGastric cancer

Binlong Chen、Yanzhong Zhao、Zichang Lin、Jiahao Liang、Jialong Fan、Yanyan Huang、Leye He、Bin Liu

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Health Management Center,The Third Xiangya Hospital,Central South University,Changsha,410013,China

Department of Urology,The Third Xiangya Hospital,Central South University,Changsha,410013,China

Department of Laboratory Medicine,The Third Xiangya Hospital,Central South University,Changsha,410013,China

College of Biology,Hunan University,Changsha,410082,China

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Changsha Municipal Natural Science FoundationConstruction Program of Hunan's innovative Province(CN)-Hightech Industry Science and Technology Innovation Leading ProjectNatural Science Foundation of Hunan ProvincePostgraduate Scientific Research Innovation Project of Hunan ProvinceChangsha Platform and Talent Plan

kq2014265Project :2020SK20022023JJ40130Project :CX20230317kq2203002

2024

10.1016/j.jpha.2023.11.011

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(5)
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