Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond

扫码查看

原文链接

国家科技期刊平台
NETL
NSTL
万方数据

外文摘要：Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,ag-gregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and as-sembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.

外文关键词：

Electron microscopySpectroscopyTraditional Chinese medicineBio-soft matterStructural characterization

作者：

Guiya Yang、Yue Liu、Yuying Hu、Yue Yuan、Yunan Qin、Quan Li、Shuangcheng Ma

展开 >

作者单位：

School of Traditional Chinese Medicine.Beijing University of Chinese Medicine,Beijing 102488,China

Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine,School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China

Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry,Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules,College of Chemistry and Chemical Engineering,Hubei University,Wuhan 430062,China

School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China

Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institutes for Food and Drug Control,Beijing 100050,China

展开 >

出版年：

2024

DOI：

10.1016/j.jpha.2024.01.011

药物分析学报(英文)

西安交通大学

药物分析学报(英文)

影响因子：0.244

ISSN：2095-1779

年,卷(期)：2024.14(6)