首页|An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy

An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy

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  • 国家科技期刊平台
  • NETL
  • NSTL
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Microwave thermotherapy(MWTT),as a treatment for tumors,lacks specificity and requires sensitizers.Most reported microwave sensitizers are single metal-organic frameworks(MOFs),which must be loaded with ionic liquids to enhance the performance in MWTT.Meanwhile,MWTT is rarely combined with other treatment modalities.Here,we synthesized a novel Fe-Cu bimetallic organic framework FeCuMOF(FCM)by applying a hydrothermal method and further modified it with methyl polyethylene glycol(mPEG).The obtained FCM@PEG(FCMP)showed remarkable heating performance under low-power microwave irradiation;it also acted as a novel nanospheres enzyme to catalyze H2O2 decompo-sition,producing abundant reactive oxygen species(ROS)to deplete glutathione(GSH)and prevent ROS clearance from tumor cells during chemodynamic treatment.The FCMP was biodegradable and demonstrated excellent biocompatibility,allowing it to be readily metabolized without causing toxic effects.Finally,it was shown to act as a suitable agent for T2 magnetic resonance imaging(MRI)in vitro and in vivo.This new bimetallic nanostructure could successfully realize two tumor treatment modalities(MWTTand chemodynamic therapy)and dual imaging modes(T2 MRI and microwave thermal imaging).Our findings represent a breakthrough for integrating the diagnosis and treatment of tumors and pro-vides a reference for developing new microwave sensitizers.

Microwave thermotherapyMetal organic frameworksGlutathione scavengingMagnetic resonance imagingSynergism

Xinyang Zhu、Chao He、Longfei Tan、Xun Qi、Meng Niu、Xianwei Meng、Hongshan Zhong

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Department of Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province,The First Affiliated Hospital of China Medical University,Shenyang,110001,China

Xixian New Area Rimag Medical Diagnosis Center,Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi,712099,China c Laboratory of Controllable Preparation and Application of Nanomaterials,Laboratory of Cryogenics,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,10019

Xixian New Area Rimag Medical Diagnosis Center,Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi,712099,China c Laboratory of Controllable Preparation and Application of Nanomaterials,Laboratory of Cryogenics,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190,China

2024

10.1016/j.jpha.2024.02.006

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(7)