首页|Targeting NTCP for liver disease treatment:A promising strategy

Targeting NTCP for liver disease treatment:A promising strategy

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  • 国家科技期刊平台
  • NETL
  • NSTL
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The sodium taurocholate co-transporting polypeptide(NTCP),a bile acids transporter,has been identi-fied as a new therapeutic target for the treatment of liver disease.This paper thoroughly investigates the function of NTCP for regulating bile acid regulation,its correlation with hepatitis B and D infections,and its association with various liver diseases.Additionally,in this review we examine recent breakthroughs in creating NTCP inhibitors and their prospective applications in liver disease treatment.While this review emphasizes the promising potential of targeting NTCP,it concurrently underscores the need for broader and more detailed research to fully understand the long-term implications and potential side effects associated with NTCP inhibition.

NTCPBile acids metabolismNTCP inhibitorViral hepatitis

Xin Tan、Yu Xiang、Jianyou Shi、Lu Chen、Dongke Yu

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Department of Pharmacy,Sichuan Provincial People's Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,610072,China

Personalized Drug Therapy Key Laboratory of Sichuan Province,School of Medicine,University of Electronic Science and Technology of China,Chengdu,610072,China

College of Medicine,University of Electronic Science and Technology,Chengdu,610072,China

Guanghan People's Hospital,Guanghan,Sichuan,618300,China

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2024

10.1016/j.jpha.2024.100979

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(9)