Emerging role of Jumonji domain-containing protein D3 in inflammatory diseases

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国家科技期刊平台
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外文摘要：Jumonji domain-containing protein D3(JMJD3)is a 2-oxoglutarate-dependent dioxygenase that specif-ically removes transcriptional repression marks di-and tri-methylated groups from lysine 27 on histone 3(H3K27me2/3).The erasure of these marks leads to the activation of some associated genes,thereby influencing various biological processes,such as development,differentiation,and immune response.However,comprehensive descriptions regarding the relationship between JMJD3 and inflammation are lacking.Here,we provide a comprehensive overview of JMJD3,including its structure,functions,and involvement in inflammatory pathways.In addition,we summarize the evidence supporting JMJD3's role in several inflammatory diseases,as well as the potential therapeutic applications of JMJD3 inhibitors.Additionally,we also discuss the challenges and opportunities associated with investigating the functions of JMJD3 and developing targeted inhibitors and propose feasible solutions to provide valuable insights into the functional exploration and discovery of potential drugs targeting JMJD3 for inflammatory diseases.

外文关键词：

JMJD3InflammationHistone demethylationInhibitor

作者：

Xiang Li、Ru-Yi Chen、Jin-Jin Shi、Chang-Yun Li、Yan-Jun Liu、Chang Gao、Ming-Rong Gao、Shun Zhang、Jian-Fei Lu、Jia-Feng Cao、Guan-Jun Yang、Jiong Chen

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作者单位：

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products,Ningbo University,Ningbo,Zhejiang,315211,China

Laboratory of Biochemistry and Molecular Biology,School of Marine Sciences,Ningbo University,Ningbo,Zhejiang,315211,China

Ningbo No.2 Hospital,Ningbo,Zhejiang,315211,China

China Ningbo Institute of Life and Health Industry,University of Chinese Academy of Sciences,Ningbo,Zhejiang,315211,China

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出版年：

2024

DOI：

10.1016/j.jpha.2024.100978

药物分析学报(英文)

西安交通大学

药物分析学报(英文)

影响因子：0.244

ISSN：2095-1779

年,卷(期)：2024.14(9)