首页|β-elemene promotes miR-127-3p maturation,induces NSCLCs autophagy,and enhances macrophage M1 polarization through exosomal communication

β-elemene promotes miR-127-3p maturation,induces NSCLCs autophagy,and enhances macrophage M1 polarization through exosomal communication

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
β-elemene has been observed to exert inhibitory effects on a multitude of tumors,primarily through multiple pathways such as the inhibition of cancer cell proliferation and the induction of apoptosis.The present study is designed to elucidate the role and underlying mechanisms of β-elemene in the thera-peutic intervention of non-small cell lung cancer(NSCLC).Both in vitro and in vivo experimental models corroborate the inhibitory potency of β-elemene on NSCLCs.Our findings indicate that β-elemene fa-cilitates the maturation of miR-127-3p by inhibiting CBX8.Functioning as an upstream regulator of MAPK4,miR-127-3p deactivates the Akt/mTOR/p70S6K pathway by targeting MAPK4,thereby inducing autophagy in NSCLCs.Additionally,β-elemene augments the packaging of miR-127-3p into exosomes via SYNCRIP.Exosomal miR-127-3p further stimulates M1 polarization of macrophages by suppressing ZC3H4.Taken together,the detailed understanding of the mechanisms through which β-elemene in-duces autophagy in NSCLCs and facilitates M1 polarization of macrophages provides compelling scientific evidence supporting its potential utility in NSCLC treatment.

β-elemenemiR-127-3pNSCLCAkt/mTOR/p70S6KMAPK4

Xiahui Wu、Jie Wu、Tingting Dai、Qiangcheng Wang、Shengjie Cai、Xuehan Wei、Jing Chen、Ziyu Jiang

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Department of Oncology,Lianyungang Integrated Traditional Chinese and Western Medicine Clinical College,Nanjing University of Chinese Medicine,Nanjing,222002,China

Department of Oncology,The First People's Hospital of Lianyungang,Lianyungang,Jiangsu,222002,China

Department of Digestive System,Pukou Hospital of Traditional Chinese Medicine,Nanjing,210000,China

Department of Oncology,Jinling Hospital,School of Medicine,Nanjing University,Nanjing,210000,China

Department of Oncology,the Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research,Nanjing,210000,China

The Third Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210028,China

Department of Biochemistry and Molecular Biology,School of Medicine,Nanjing University of Chinese Medicine,Nanjing,210023,China

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2024

10.1016/j.jpha.2024.03.002

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(9)