首页|Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC

Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Trastuzumab has improved survival rates in human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC),but drug resistance leads to treatment failure.Natural killer(NK)cell-mediated antibody-dependent cell cytotoxicity(ADCC)represents an essential antitumor immune mechanism of trastuzumab.Traditional Chinese medicine(TCM)has been used for centuries to treat diseases because of its capacity to improve immune responses.Xianling Lianxia formula(XLLXF),based on the principle of"strengthening body and eliminating toxin",exhibits a synergistic effect in the trastuzumab treatment of patients with HER2-positive BC.Notably,this synergistic effect of XLLXF was executed by enhancing NK cells and ADCC,as demonstrated through in vitro co-culture of NK cells and BC cells and in vivo inter-vention experiments.Mechanistically,the augmented impact of XLLXF on NK cells is linked to a decrease in cytokine inducible Src homology 2(SH2)containing protein(CISH)expression,which in turn activates the Janus kinase 1(JAK1)/signal transducer and activator of transcription 5(STAT5)pathway.Collectively,these findings suggested that XLLXF holds promise for enhancing NK cell function and sensitizing pa-tients with HER2-positive BC to trastuzumab.

HER2-positive breast cancerTraditional chinese medicineTrastuzumabNK cellADCC effect

Feifei Li、Youyang Shi、Mei Ma、Xiaojuan Yang、Xiaosong Chen、Ying Xie、Sheng Liu

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Department of Breast Surgery,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai,200030,China

Institute of Chinese Traditional Surgery,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai,200030,China

Institute of Toxicology,School of Public Health,Lanzhou University,Lanzhou 730000,China

Department of General Surgery,Comprehensive Breast Health Center,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200001,China

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2024

10.1016/j.jpha.2024.100977

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(10)