首页|SnoRNAs:The promising targets for anti-tumor therapy

SnoRNAs:The promising targets for anti-tumor therapy

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Recently,small nucleolar RNAs(snoRNAs)have transcended the genomic"noise"to emerge as pivotal molecular markers due to their essential roles in tumor progression.Substantial evidence indicates a strong association between snoRNAs and critical clinical features such as tumor pathology and drug resistance.Historically,snoRNA research has concentrated on two classical mechanisms:2'-O-ribose methylation and pseudouridylation.This review specifically summarizes the novel regulatory mecha-nisms and functional patterns of snoRNAs in tumors,encompassing transcriptional,post-transcriptional,and post-translational regulation.We further discuss the synergistic effect between snoRNA host genes(SNHGs)and snoRNAs in tumor progression.More importantly,snoRNAs extensively contribute to the development of tumor cell resistance as oncogenes or tumor suppressor genes.Accordingly,we provide a comprehensive review of the clinical diagnosis and treatment associated with snoRNAs and explore their significant potential as novel drug targets.

snoRNACancersnoRNA host geneMultidrug resistanceTargeted therapyTumor immune microenvironment

Xiaoyun Hu、Wanlin Cui、Min Liu、Fangxiao Zhang、Yingqi Zhao、Mingrong Zhang、Yuhang Yin、Yalun Li、Ying Che、Xianglong Zhu、Yuxuan Fan、Xiaolan Deng、Minjie Wei、Huizhe Wu

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Department of Pharmacology,School of Pharmacy,China Medical University,Shenyang,110122,China

Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation,Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center,Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors,Ministry of Education,China Medical University,Shenyang,110122,China

Scientific Experimental Center,School of Pharmacy,China Medical University,Shenyang,110122,China

The Second Department of Infectious Diseases,The First Affiliated Hospital of China Medical University,Shenyang,110001,China

Department of Anorectal Surgery,The First Affiliated Hospital of China Medical University,Shenyang,110001,China

Department of Systems Biology,Beckman Research Institute of City of Hope,Monrovia,CA,91016,USA

Shenyang K

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2024

10.1016/j.jpha.2024.101064

药物分析学报(英文)
西安交通大学

药物分析学报(英文)

影响因子：0.244
ISSN：2095-1779
年,卷(期)：2024.14(11)