药物流行病学杂志2024,Vol.33Issue(1) :9-18.DOI:10.12173/j.issn.1005-0698.202304130

新型抗肿瘤药物致神经系统疾病综述及风险信息管理

Review and risk information management of neuropathy induced by emerging anti-tumor drugs

吕丰 宋伟 辛梦茹 谢地 张文庆 何文 胡汉昆
药物流行病学杂志2024,Vol.33Issue(1) :9-18.DOI:10.12173/j.issn.1005-0698.202304130

新型抗肿瘤药物致神经系统疾病综述及风险信息管理

Review and risk information management of neuropathy induced by emerging anti-tumor drugs

吕丰 1宋伟 1辛梦茹 2谢地 2张文庆 2何文 1胡汉昆3
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作者信息

  • 1. 武汉大学人民医院药学部(武汉 430060)
  • 2. 武汉大学中南医院药学部(武汉 430071)
  • 3. 武汉大学中南医院药学部(武汉 430071);北京神经内科学会全科医学专业委员会(北京 100012)
  • 折叠

摘要

随着越来越多的新型抗肿瘤药物获批上市,对这些药物的临床安全性监测和风险信息管理成为迫切需要.药源性神经系统疾病存在起病隐匿、进展迅速和治疗棘手等特点,最终可能导致治疗失败.因此,充分了解新型抗肿瘤药物所致神经系统疾病的风险,并进行监护和预警,及时处理和上报,可大幅降低药源性疾病的发生和危害程度.本文对新型抗肿瘤药物所致神经系统疾病展开综述,介绍了此类药物临床使用的警戒体系和风险信息管理手段,以期为指导临床合理用药、减少药源性疾病的发生提供借鉴.

Abstract

As an increasing number of emerging anti-tumor drugs are approved and marketed,the imperative for clinical safety monitoring and risk information management has grown significantly.Drug-induced neuropathy associated with these drugs exhibit characteristics such as insidious onset,rapid progression,and challenging treatment,ultimately leading to treatment failures.Therefore,a comprehensive understanding of the risk of neuropathy induced by emerging anti-tumor drugs,coupled with risk surveillance and early warning,as well as management and reporting,can significantly reduce the incidence and severity of drug-related diseases.This paper provides a review of the neuropathy caused by emerging anti-tumor drugs,introduces the pharmacovigilance system and risk information management measures in clinical usage,aiming to provide a reference for guiding the rational clinical use and minimizing the incidence of drug-induced diseases.

关键词

新型抗肿瘤药物/药源性神经系统疾病/药物风险信息管理

Key words

Emerging anti-tumor drugs/Drug-induced neuropathy/Drug risk information management

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基金项目

中国药学会医院药学专业委员会科研专项资助项目(CPA-Z05-ZC-2022-002)

出版年

2024
药物流行病学杂志
中国药学会 武汉医药(集团)股份有限公司

药物流行病学杂志

CSTPCD
影响因子:0.746
ISSN:1005-0698
参考文献量56
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