摘要
目的 观察滋肾宁心胶囊联合替米沙坦治疗围绝经期高血压的疗效,及对患者血压、生化指标、中医症状积分的影响.方法 300例围绝经期高血压患者随机分为对照组和观察组各150例.对照组给予替米沙坦治疗,观察组在对照组治疗基础上加用滋肾宁心胶囊,两组疗程均为8周.观察比较两组患者治疗前后24 h动态血压及其变异系数(24 h平均收缩压及其变异系数、24 h平均舒张压及其变异系数)、性激素水平(血清雌二醇、促卵泡生成素、睾酮、孕酮)、血脂(三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)、肾素和超敏C反应蛋白水平,以及中医症状积分变化,评价两组疗效.结果 治疗后,两组患者的24 h平均收缩压及其变异系数、24 h平均舒张压及其变异系数,性激素、血脂、肾素和超敏C反应蛋白水平,以及中医症状积分等指标均较前明显改善(P＜0.05),且观察组各项指标均优于对照组(P＜0.05).观察组治疗总有效率明显高于对照组(P＜0.05).两组不良反应发生率差异无统计学意义(P＞0.05).结论 滋肾宁心胶囊联合替米沙坦治疗围绝经期高血压临床疗效显著,可有效降低血压、缓解症状,改善性激素、血脂、肾素和超敏C反应蛋白水平.
Abstract
Objective To observe the efficacy of Zishen Ningxin capsule combined with telmisartan in the treatment of perimenopausal hypertension,and its influence on the patients'blood pressure,biochemical indexes and TCM symptom scores.Methods 300 patients with perimenopausal hypertension were randomly divided into control group and observation group with 150 patients in each group.The control group was given telmisartan treatment,and the observation group was given Zishen Ningxin capsule on the basis of the control group.The treatment course of both groups was 8 weeks.The dynamic blood pressure and coefficient of variation of blood pressure at 24 h before and after treatment were observed and compared between two groups(24 h systolic blood pressure and coefficient of variation,24 h diastolic blood pressure and its coefficient of variation),sex hormone levels(serum estradiol,follicle stimulating hormone,testosterone,progesterone),blood lipid levels(triacylglycerol,total cholesterol,low density lipoprotein cholesterol,high density lipoprotein cholesterol),renin and hypersensitive C-reactive protein levels,as well as the changes of TCM symptom score were evaluated for the efficacy of the two groups.Results After treatment,the 24 h systolic blood pressure and its coefficient of variation,24 h diastolic blood pressure and its coefficient of variation,the levels of sex hormones,blood lipids,renin and hypersensitive C-reactive protein,as well as TCM symptom scores in two groups were significantly improved(P＜0.05),and all indexes in the observation group were better than those in the control group(P＜0.05).The total effective rate of observation group was significantly higher than that of control group(P＜0.05).There was no significant difference of the incidence of adverse reactions in the two groups(P＞0.05).Conclusion Zishen Ningxin capsule combined with telmisartan has significant clinical efficacy in the treatment of perimenopausal hypertension,which can effectively reduce blood pressure,relieve symptoms,improve the levels of sex hormones,blood lipids,renin and hypersensitive C-reactive protein.
维普
万方数据