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基于加权TOPSIS法的奥扎格雷钠药物利用评价

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目的 基于加权优劣解距离(TOPSIS)法评价奥扎格雷钠的临床使用,为提高奥扎格雷钠合理使用提供参考依据。方法 参考奥扎格雷钠药品说明书、相关指南和文献,并通过德尔菲法,制定奥扎格雷钠药物利用评价标准,采用属性层次分析法赋予各指标权重,并通过TOPSIS法对河南省直第三人民医院2021年1月—2022年4月108例出院患者使用奥扎格雷钠的合理性进行评价。结果 两轮专家咨询的问卷回收率均为100%,权威系数(Cr)分别为0。85,0。83(>0。70),且专家对标准各条目给予了充分肯定。纳入评价的108份病历中,37份(34。26%)判定为合理,52份(48。15%)判定为基本合理,19份(17。59%)判定为不合理。不合理用药主要表现为超适应证用药、给药时机不恰当、用药疗程不足、疗效和实验室监测不充分等方面。结论 基于加权TOPSIS法进行用药合理性评估更直观、科学。该院奥扎格雷钠的使用总体较为规范,但在用药疗程、适应证、给药时机等方面存在问题,应加强医师与药师协作,建立完善药学干预机制,促进其临床合理应用。
Drug use evaluation of ozagrel sodium based on weighted TOPSIS method
Objective To establish evaluation of ozagrel sodium by weighted TOPSIS method so as to provide a reference for improving the rational use of ozagrel sodium.Methods Based on the drug instructions,guidelines,relevant literatures and Delphi method,the evaluation criteria for the clinical rationality of ozagrel sodium were formulated.Attribute hierarchical model(AHM)was used to assign weights to the indicators,the weighted TOPSIS method was employed to analyze and evaluate the rationality of 108 patients that discharged from the Third People's Hospital of Henan Province from January 2021 to April 2022.Results The reponse rates of two rounds of expert advice questionnaires were 100%,the authoritative coefficients(Cr)were 0.85,0.83(>0.70),and the experts fully affirmed the items of the standard.Among the 108 cases evaluated,37 cases(34.26%)were judged to be reasonable,52 cases(48.15%)were judged to be basically reasonable and 19 cases(17.59%)were judged to be unreasonable.The main unreasonable problems were manifested in indications,the timing of administration,drug course and monitoring of efficacy and laboratory parameters.Conclusion The method of DUE of ozagrel sodium based on weighted TOPSIS is more comprehensively and intuitively.The application of ozagrel sodium in the hospital is relatively standardized,but there are problems in the course of medication,indications,and timing of administration.So it is necessary to promote the rational use by strengthening the cooperation between pharmacists and physicians,and improving pharmaceutical intervention.

Ozagrel sodiumDrug use evaluationWeighted TOPSIS methodDelphi methodRational drug use

朱珊珊、王娜、蔡慧雅、张进华

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河南省直第三人民医院药剂科(郑州 450000)

重庆医科大学附属第二医院药学部(重庆 400010)

漳州市第二医院药剂科(福建漳州 363199)

福建省妇幼保健院药剂科(福州 350001)

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奥扎格雷钠 药物利用评价标准 加权优劣解距离法 德尔菲法 合理用药

2024

药物流行病学杂志
中国药学会 武汉医药(集团)股份有限公司

药物流行病学杂志

CSTPCD
影响因子:0.746
ISSN:1005-0698
年,卷(期):2024.33(2)
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