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瑞舒伐他汀钙片致颞下颌关节脱位1例

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1例50岁女性患者因体检发现双侧颈动脉硬化并右侧斑块形成,予瑞舒伐他汀钙片(20 mg,po,qn)治疗25 d后患者出现颞下颌关节脱位,给予手法复位后继续用药,再次发生不良反应。既往患者身体健康,无外伤史及口腔科相关疾病史,无药物过敏史,发病时患者未大声张口,无外力因素影响,用药期间未联合使用其他药物,药品不良反应关联性评价结果为"很可能"。给予手法复位等治疗后随访3个月,患者未再出现颞下颌关节脱位。提示临床使用瑞舒伐他汀时应注意加强用药观察。
A case of temporomandibular joint dislocation caused by rosuvastatin calcium tablets
A 50-year-old female presented with bilateral cervical arteriosclerosis and right-sided plaque formation,after 25 d of treatment with rosuvastatin calcium tablets(20 mg,po,qn),the patient developed temporomandibular joint dislocation,the adverse reactions occurred again after giving manipulative repositioning.The patients were healthy,had no history of trauma and related diseases in stomatology,no history of drug allergy,patients did not open their mouth loudly at the onset of the disease,no external factors affecting the use of drugs during the combined use of other drugs.It was considered"very likely"that the dislocation of the jaw joint was caused by rosuvastatin calcium tablets.The patients were followed up for 3 months after the treatment of manipulative repositioning and other treatments,did not have any further dislocation of the temporomandibular joint dislocation.It is suggested that when using rosuvastatin calcium in clinical practice,attention should be paid to strengthening drug observation to ensure drug safety.

Rosuvastatin calcium tabletsTemporomandibular joint dislocationAdverse drug reactions

陈集志、李博涵、夏国际

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中国人民解放军联勤保障部队第九○八医院药剂科(南昌 330002)

南昌大学医学院临床医学系(南昌 330031)

中国人民解放军联勤保障部队第九○八医院呼吸内科(南昌 330002)

瑞舒伐他汀钙 颞下颌关节脱位 药品不良反应

2024

药物流行病学杂志
中国药学会 武汉医药(集团)股份有限公司

药物流行病学杂志

CSTPCD
影响因子:0.746
ISSN:1005-0698
年,卷(期):2024.33(2)
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