1例既往万古霉素假性过敏患者骨髓炎术后复发的药学监护
Pharmaceutical care of postoperative recurrence of osteomyelitis in a patient with previous vancomycin pseudoallergy
罗伟伟 1金建峰 1杨琼 1郑盼盼 1周靓昉 1钟丹妮1
作者信息
- 1. 宁波市第六医院药学部(浙江宁波 315100)
- 折叠
摘要
1例既往使用万古霉素治疗后出现皮疹的骨髓炎患者复发人院,拟行"硫酸钙-万古霉素植入术".该患者既往皮疹,经临床药师鉴别为红人综合征(RMS)而非真性药物过敏反应.同时针对既往发生RMS的患者能否行"硫酸钙-万古霉素植入术",临床药师进行文献分析,建议可在密切监护下继续进行手术.患者术后未出现RMS及过敏反应,且病情好转.本文临床药师从RMS、速发型过敏反应的鉴别入手,同时对万古霉素局部使用与RMS的发生风险进行文献复习,对后续治疗方案提出建议,为临床安全用药及类似疾病的治疗提供参考.
Abstract
A patient with osteomyelitis who developed a rash after previous treatment with vancomycin was admitted to the hospital due to a recurrence of osteomyelitis.After admission,the orthopedic doctor intended to perform a"calcium sulfate vancomycin implantation surgery"on him.Clinical pharmacist identified the patient's previous rash reaction as red man syndrome(RMS)rather than genuine drug allergy.At the same time,in response to the clinical doubt of whether patients with previous RMS can undergo"calcium sulfate vancomycin implantation surgery",clinical pharmacists reviewed and analyzed the literature,and suggested that the surgery can continue under close monitoring.The patient did not experience RMS or allergic reactions after surgery,and the condition improved.In this paper,the clinical pharmacists started with the identification of RMS and rapid allergic reactions,reviewed the literature on the local use of vancomycin and the risk of RMS,and provide suggestions for subsequent treatment,and also provide references for clinical safe drug use and treatment of similar diseases.
关键词
万古霉素/假性过敏/红人综合征/临床药师/骨髓炎Key words
Vancomycin/Pseudoallergic/Red man syndrome/Clinical pharmacist/Osteomyelitis引用本文复制引用
基金项目
宁波市鄞州区卫生健康科技计划项目(2023Y20)
出版年
2024
NETL
NSTL
万方数据