目的 利用CiteSpace软件分析水蛭在医药方面的文献，了解水蛭相关研究的现状、热点和发展趋势，为水蛭领域的研究学者提供参考。方法 系统检索1996-2022年CNKI和Web of Science数据库中收录的水蛭在医药研究领域的相关文献，运用CiteSpace 6。1R3软件对其发文量、作者、研究机构、国家，关键词共现、聚类、突现等进行文献计量和可视化分析。结果 共纳入CNKI数据库中文文献1 115篇以及Web of Science数据库英文文献237篇文献。中英文文献分析表明，作者史红专中文文献发文量最多，作者Hildebrandt英文发文量最多;山东中医药大学和中国科学院是分别是中、英发文量最多的机构;发表英文文献最多的国家为美国。中英文关键词共现及聚类分析显示，中文文献注重研究水蛭的有效成分水蛭素，包括分子结构、药理药效，以及治疗血栓、冠心病、肾病等疾病的作用机制等，同时关注不同种类水蛭活性成分的差异;英文文献除此之外还注重研究活体水蛭的临床外用。关键词突现提示，作用机制、水蛭素类似物的寻找和合成、配伍应用时的药效机制等不仅是目前的研究热点，也可能是未来的热点方向。结论 水蛭成分分析、水蛭治疗心血管疾病、慢性肾脏病等疾病的药理作用机制研究始终是本领域研究热点;水蛭素类似物、配伍应用的药效机制、网络药理、分子对接等可能是水蛭的未来研究热点和趋势。
Research status and hotspot analysis of leech in the field of medicine based on bibliometrics
Objective To analyze the literature of leech in medicine using CiteSpace knowledge map,comprehensively understand the research status,hotspots and development trends of component analysis and pharmacological effects of leech,and provide reference for researchers in the field of leech.Methods CiteSpace 6.1 R3 software was used to analyze the relevant literature of leech in the field of medical research in CNKI and Web of Science databases from 1996 to 2022.The bibliometric and visual analysis of the number of articles,authors,research institutions,keyword co-occurrence,clustering and emergence were carried out.Results A total of 1 115 Chinese articles in CNKI database and 237 English articles in Web of Science database were included.The analysis of Chinese and English literature showed that the author Shi Hongzhuan had the largest number of Chinese articles,and the German author Hildebrandt had the largest number of English articles.Shandong University of Traditional Chinese Medicine and Chinese Academy of Sciences were the institutions with the largest number of articles in Chinese and English respectively.The country with the most published English literature is the United States.Chinese and English keyword co-occurrence and cluster analysis showed that Chinese literature focused on the study of its active ingredient hirudin,including molecular structure,pharmacological efficacy,mechanism of treating thrombosis,coronary heart disease,kidney disease and other diseases,and paid attention to the differences in the active ingredients of different types of leeches.In addition,English literature focused on the clinical external use of living leeches.The emergence of keywords suggested that the mechanism of action,the search and synthesis of hirudin analogues,and the pharmacodynamic mechanism of compatibility application were not only the current research hotspots,but also the future hot spots.Conclusion The analysis of leech components,the pharmacological mechanism of leech in the treatment of cardiovascular diseases,chronic kidney diseases and other diseases have always been the research hotspots.Hirudin analogues,the pharmacodynamic mechanism of compatibility application,network pharmacology,molecular docking and so on may be the future research hotspots and trends of leeches.
LeechBibliometricsVisual analysisHotspot and trendLiving application
万方数据
维普
